{"id":"63720ea1-21a7-5668-9f56-38d9e36151cb","stable_key":"10aa417f-4b03-599f-a453-4aa09edeb27c:alanine-pdac-snat2","predicate":"supports_concentration","statement":"Loss of SLC38A2 prevented human PDAC cells from effectively taking up and concentrating environmental alanine.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"81170608-08fa-5e31-b5a8-2f3012abffcb","mechanism_event_label":"An intact uptake system can be as important as having alanine outside the cell.","subject":{"id":"d892d59f-d137-5a53-9b16-10e4b6732951","slug":"slc38a2","display_name":"Human sodium-coupled neutral amino acid transporter 2 / SLC38A2","entity_type_key":"protein"},"object":{"id":"b6cbd71c-0a75-5ed9-8e8f-63cb15274697","slug":"human-pdac-intracellular-alanine","display_name":"Intracellular alanine concentration in human PDAC cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"81170608-08fa-5e31-b5a8-2f3012abffcb","stable_key":"10aa417f-4b03-599f-a453-4aa09edeb27c:alanine-pdac-snat2-event","event_type":"observed_relationship","label":"An intact uptake system can be as important as having alanine outside the cell.","description":"Loss of SLC38A2 prevented human PDAC cells from effectively taking up and concentrating environmental alanine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d892d59f-d137-5a53-9b16-10e4b6732951","slug":"slc38a2","display_name":"Human sodium-coupled neutral amino acid transporter 2 / SLC38A2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b6cbd71c-0a75-5ed9-8e8f-63cb15274697","slug":"human-pdac-intracellular-alanine","display_name":"Intracellular alanine concentration in human PDAC cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ebdc4461-c059-563e-88b0-422c21fdaa25","slug":"alanine","display_name":"L-Alanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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