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Loss of one scaffold does not eliminate every PTH response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"PTH could remove the transporter from the brush border even when one scaffold was absent.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p16987995] Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. (2007). https://pubmed.ncbi.nlm.nih.gov/16987995/ DOI: 10.1152/ajpcell.00126.2006","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Renal proximal tubule brush-border membrane","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"03709aff-0467-56c2-befe-1dbd8071b088","evidence_kind":"source_excerpt","locator":"Lines 399-410","start_line":399,"end_line":410,"excerpt":"### phosphorus-pth-internalization\nPTH-(1–34) induced NaPi-IIa internalization in both wild-type and Nherf1-deficient mice.\nCondition category: normal\nnutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: PTH could remove the transporter from the brush border even when one scaffold was absent.\norganism: Mouse\ntissue_or_cell_type: Renal proximal tubule brush-border membrane\nexperimental_model: Receptor-fragment stimulation, knockout and signaling-bypass experiments\nlimitations: Apical and basolateral receptor routes differ. Loss of one scaffold does not eliminate every PTH response.\nexposure: PTH-(1–34), apically selective PTH-(3–34), PKC/PKA pathway stimulation\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/16987995.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c5a055252ffc61da98e24d1de3a1733ee7aea678aded8cbdf071d18ad707d0bc\", \"start_char\": 0, \"end_char\": 1699, \"text_sha256\": \"c5a055252ffc61da98e24d1de3a1733ee7aea678aded8cbdf071d18ad707d0bc\"}\n[phosphorus-p16987995] Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. 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