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Abstract-only exposure resolution.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Vitamin C changed methyl marks on histone proteins in cultured mouse fibroblasts.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[c-reg-wang] The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. (2011). https://pubmed.ncbi.nlm.nih.gov/22100412/ DOI: 10.1016/j.stem.2011.10.005","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Embryonic fibroblasts","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ee840301-5eed-5b11-bd12-57707a7c79c1","evidence_kind":"source_excerpt","locator":"Lines 1089-1101","start_line":1089,"end_line":1101,"excerpt":"### c-reg-h3k36-mark-reduction\nVitamin C treatment reduced H3K36me2/3 in mouse embryonic fibroblasts during culture and reprogramming, linking the intervention to histone methylation changes.\nCondition category: normal\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Vitamin C changed methyl marks on histone proteins in cultured mouse fibroblasts.\norganism: Mus musculus\ntissue_or_cell_type: Embryonic fibroblasts\nexperimental_model: Mouse embryonic fibroblasts in culture and reprogramming; primary abstract-level result\nlimitations: No direct claim that Kdm2a/b remove H3K36me3; the combined cellular mark change may involve other enzymes. Abstract-only exposure resolution.\nexposure: Vitamin C-supplemented cell culture; exact preparation, dose and duration not recovered from accessible primary abstract.\ncross_nutrient: false\nevidence_location: Primary abstract H3K36me2/3 result\n[c-reg-wang] The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. (2011). https://pubmed.ncbi.nlm.nih.gov/22100412/ DOI: 10.1016/j.stem.2011.10.005","model_system":"Mouse embryonic fibroblasts in culture and reprogramming; primary abstract-level result","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [c-reg-wang] The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. 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