{"id":"62ca6337-3280-561a-ab85-ea9589a8c5cb","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-receptor","predicate":"binds","statement":"Surface plasmon resonance supported nanomolar-affinity EGCG binding to 67LR; receptor expression conferred cellular responsiveness.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e59a674d-5e66-584d-a447-6a02f02b48bf","mechanism_event_label":"A cell-surface receptor can make cells responsive to EGCG.","subject":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"object":{"id":"85e65054-3bd4-53b5-a5f0-2286061f8bf0","slug":"laminin-receptor-67kda","display_name":"67-kDa laminin receptor state / 67LR","entity_type_key":"protein_state"},"evidence_count":1,"mechanism_event":{"id":"e59a674d-5e66-584d-a447-6a02f02b48bf","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-receptor-event","event_type":"observed_relationship","label":"A cell-surface receptor can make cells responsive to EGCG.","description":"Surface plasmon resonance supported nanomolar-affinity EGCG binding to 67LR; receptor expression conferred cellular responsiveness.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"85e65054-3bd4-53b5-a5f0-2286061f8bf0","slug":"laminin-receptor-67kda","display_name":"67-kDa laminin receptor state / 67LR","entity_type_key":"protein_state"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Receptor binding and cancer-cell expression experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"67LR is recorded as the receptor state, not equated with all functions of the 37-kDa RPSA precursor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A cell-surface receptor can make cells responsive to EGCG.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A receptor for green tea polyphenol EGCG. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15024383/ · DOI 10.1038/nsmb743","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"804d2581-d6fe-5e9f-8d2e-4c750065a3bd","evidence_kind":"source_excerpt","locator":"Lines 20-26","start_line":20,"end_line":26,"excerpt":"## egcg-receptor\nA cell-surface receptor can make cells responsive to EGCG.\nSurface plasmon resonance supported nanomolar-affinity EGCG binding to 67LR; receptor expression conferred cellular responsiveness.\nModel: Receptor binding and cancer-cell expression experiments.\nLimitations: 67LR is recorded as the receptor state, not equated with all functions of the 37-kDa RPSA precursor.\nEvidence access: primary abstract.\nA receptor for green tea polyphenol EGCG. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15024383/ · DOI 10.1038/nsmb743","model_system":"Receptor binding and cancer-cell expression experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}