{"id":"6282396d-4677-5d5b-bdd9-fd872a00e14a","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-atbc-prostate-incidence","predicate":"reduces_observed","statement":"The ATBC secondary analysis found 32% lower prostate-cancer incidence among men assigned alpha-tocopherol versus those not assigned it.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"2c177975-737a-5a11-ab28-be0db29769e1","mechanism_event_label":"A lower-dose trial in male smokers found fewer prostate-cancer diagnoses.","subject":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"object":{"id":"683e9449-f86a-53cb-b397-8a2ea82fcad7","slug":"prostate-cancer-incidence","display_name":"Prostate cancer incidence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2c177975-737a-5a11-ab28-be0db29769e1","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-atbc-prostate-incidence-event","event_type":"observed_intervention","label":"A lower-dose trial in male smokers found fewer prostate-cancer diagnoses.","description":"The ATBC secondary analysis found 32% lower prostate-cancer incidence among men assigned alpha-tocopherol versus those not assigned it.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"73c24cd4-9ae8-5897-8359-fa4d9e8edecb","slug":"beta-carotene","display_name":"All-trans-beta-carotene","entity_type_key":"small_molecule"},"role":"factorial_trial_agent","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"683e9449-f86a-53cb-b397-8a2ea82fcad7","slug":"prostate-cancer-incidence","display_name":"Prostate cancer incidence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"ATBC randomized factorial trial secondary prostate-cancer endpoint; 29133 Finnish male smokers aged 50–69","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Alpha-tocopherol 50 mg/day with or without beta-carotene 20 mg/day; median 6.1 years.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Secondary cancer endpoint in male smokers; differs from SELECT in dose, population and ascertainment. An opposite trial result is not automatically a same-condition biological contradiction. This result and SELECT must retain their different populations and regimens; neither supplies the molecular explanation for their difference.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A lower-dose trial in male smokers found fewer prostate-cancer diagnoses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[e-clin-atbc1998] Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. (1998). https://pubmed.ncbi.nlm.nih.gov/9521168/ DOI: 10.1093/jnci/90.6.440","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Prostate and whole-person outcomes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b8d3d2af-eb49-5d99-9c6a-59d542deae23","evidence_kind":"source_excerpt","locator":"Lines 1323-1334","start_line":1323,"end_line":1334,"excerpt":"### e-clin-atbc-prostate-incidence\nThe ATBC secondary analysis found 32% lower prostate-cancer incidence among men assigned alpha-tocopherol versus those not assigned it.\nCondition category: normal\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A lower-dose trial in male smokers found fewer prostate-cancer diagnoses.\norganism: Homo sapiens\ntissue_or_cell_type: Prostate and whole-person outcomes\nexperimental_model: ATBC randomized factorial trial secondary prostate-cancer endpoint; 29133 Finnish male smokers aged 50–69\nlimitations: Secondary cancer endpoint in male smokers; differs from SELECT in dose, population and ascertainment. An opposite trial result is not automatically a same-condition biological contradiction. This result and SELECT must retain their different populations and regimens; neither supplies the molecular explanation for their difference.\nexposure: Alpha-tocopherol 50 mg/day with or without beta-carotene 20 mg/day; median 6.1 years.\ncross_nutrient: true\n[e-clin-atbc1998] Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. (1998). https://pubmed.ncbi.nlm.nih.gov/9521168/ DOI: 10.1093/jnci/90.6.440","model_system":"ATBC randomized factorial trial secondary prostate-cancer endpoint; 29133 Finnish male smokers aged 50–69","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [e-clin-atbc1998] Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. (1998). https://pubmed.ncbi.nlm.nih.gov/9521168/ DOI: 10.1093/jnci/90.6.440","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3ac41dba-4727-5116-a556-ac3bbb0dc41c","stable_key":"import-e0ea2d6a-7429-5e9f-b774-41e5e3288da3","title":"Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a90b6565e092c6a2da07f74cf758792c2cf63b40746260c8ff12bd64322c36f4","revision_id":"956793d1-23e4-5397-9291-25c1732a8e02","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}