{"id":"625295cc-efd8-5727-b2fd-91b71260912c","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-mg-zinc-mixture-sleep","predicate":"improves","statement":"The combination improved global PSQI sleep-quality scores compared with placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a807ab8e-87e6-5b70-8240-16e443f62518","mechanism_event_label":"The tested product helped this outcome, but it does not isolate magnesium, zinc or melatonin.","subject":{"id":"f6834efa-c172-5e8e-83c6-114d43d985bc","slug":"melatonin-magnesium-zinc-mixture","display_name":"Melatonin, magnesium and zinc study mixture","entity_type_key":"chemical_species"},"object":{"id":"94f6ec4f-ffc9-5cdc-8d93-6dbf73f6625a","slug":"subjective-global-sleep-quality","display_name":"Global subjective sleep quality on PSQI","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a807ab8e-87e6-5b70-8240-16e443f62518","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-mg-zinc-mixture-sleep-event","event_type":"observed_intervention","label":"The tested product helped this outcome, but it does not isolate magnesium, zinc or melatonin.","description":"The combination improved global PSQI sleep-quality scores compared with placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"role":"component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"component","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"component","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"f6834efa-c172-5e8e-83c6-114d43d985bc","slug":"melatonin-magnesium-zinc-mixture","display_name":"Melatonin, magnesium and zinc study mixture","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"94f6ec4f-ffc9-5cdc-8d93-6dbf73f6625a","slug":"subjective-global-sleep-quality","display_name":"Global subjective sleep quality on PSQI","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/melatonin-research/21226679.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2381a465728ea91061029d1d1d565623a15bdb941acf0cc9dbd2ed872fda32cf\", \"start_char\": 0, \"end_char\": 1911, \"text_sha256\": \"2381a465728ea91061029d1d1d565623a15bdb941acf0cc9dbd2ed872fda32cf\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind placebo-controlled mixture trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"5 mg melatonin, 225 mg magnesium and 11.25 mg zinc nightly for eight weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Three active ingredients without separate ingredient arms; cannot demonstrate synergy or identify which ingredient caused the improvement. Single facility and short duration.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Melatonin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"43 elderly long-term-care residents with primary insomnia","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The tested product helped this outcome, but it does not isolate magnesium, zinc or melatonin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[melatonin-p21226679] The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial. (2011). https://pubmed.ncbi.nlm.nih.gov/21226679/ DOI: 10.1111/j.1532-5415.2010.03232.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Subjective and device-estimated sleep","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3e63daa2-354b-5434-837f-72712a9196ad","evidence_kind":"source_excerpt","locator":"Lines 825-836","start_line":825,"end_line":836,"excerpt":"### melatonin-mg-zinc-mixture-sleep\nThe combination improved global PSQI sleep-quality scores compared with placebo.\nCondition category: normal\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The tested product helped this outcome, but it does not isolate magnesium, zinc or melatonin.\norganism: 43 elderly long-term-care residents with primary insomnia\ntissue_or_cell_type: Subjective and device-estimated sleep\nexperimental_model: Double-blind placebo-controlled mixture trial\nlimitations: Three active ingredients without separate ingredient arms; cannot demonstrate synergy or identify which ingredient caused the improvement. Single facility and short duration.\nexposure: 5 mg melatonin, 225 mg magnesium and 11.25 mg zinc nightly for eight weeks\nevidence_span: {\"source_cache\": \"artifacts/melatonin-research/21226679.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2381a465728ea91061029d1d1d565623a15bdb941acf0cc9dbd2ed872fda32cf\", \"start_char\": 0, \"end_char\": 1911, \"text_sha256\": \"2381a465728ea91061029d1d1d565623a15bdb941acf0cc9dbd2ed872fda32cf\"}\n[melatonin-p21226679] The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial. (2011). https://pubmed.ncbi.nlm.nih.gov/21226679/ DOI: 10.1111/j.1532-5415.2010.03232.x","model_system":"Double-blind placebo-controlled mixture trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [melatonin-p21226679] The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial. 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