{"id":"623d7f3d-d0e9-5860-9ebf-97a17732b5b9","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-bitter14","predicate":"activates","statement":"TAS2R14 was the other human receptor identified in the functional screen as mediating steviol-glycoside bitter off-taste.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"36fe718a-3770-51a8-bbd9-1a13e527b283","mechanism_event_label":"Two separately stored receptors connect the taste profile to other research.","subject":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"object":{"id":"082e8013-d379-5040-b7cc-782645735ecf","slug":"tas2r14","display_name":"Human bitter taste receptor / TAS2R14","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"36fe718a-3770-51a8-bbd9-1a13e527b283","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-bitter14-event","event_type":"observed_relationship","label":"Two separately stored receptors connect the taste profile to other research.","description":"TAS2R14 was the other human receptor identified in the functional screen as mediating steviol-glycoside bitter off-taste.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"082e8013-d379-5040-b7cc-782645735ecf","slug":"tas2r14","display_name":"Human bitter taste receptor / TAS2R14","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cell-based receptor screening.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A tongue receptor response does not automatically reproduce in intestinal or immune tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Two separately stored receptors connect the taste profile to other research.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Human psychometric and taste receptor responses to steviol glycosides. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22616809/ · DOI 10.1021/jf301297n","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"623af827-c2da-5e5d-9c15-7bdb2c0a4ec6","evidence_kind":"source_excerpt","locator":"Lines 162-168","start_line":162,"end_line":168,"excerpt":"## stevia-bitter14\nTwo separately stored receptors connect the taste profile to other research.\nTAS2R14 was the other human receptor identified in the functional screen as mediating steviol-glycoside bitter off-taste.\nModel: Human cell-based receptor screening.\nLimitations: A tongue receptor response does not automatically reproduce in intestinal or immune tissue.\nEvidence access: Primary abstract\nHuman psychometric and taste receptor responses to steviol glycosides. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22616809/ · DOI 10.1021/jf301297n","model_system":"Human cell-based receptor screening.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a36a82c2f8a0a971ea43e9e742db65f45848d13ab77310c0dd6b5cd55e31fc16","revision_id":"ea0355af-a926-511a-a7f2-1750baa95a8d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}