{"id":"6221f97d-8e5b-5515-8c09-9d827e665f65","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-nmn-cell-nad","predicate":"increases_in_recorded_comparison","statement":"NMN plus apigenin increased NAD+ and the NAD+/NADH ratio in the 2026 oxidative-stress musculoskeletal-cell experiments.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"67f6547a-3034-5df8-8fdd-f0ff1e6e1e92","mechanism_event_label":"NMN plus apigenin increased NAD+ and the NAD+/NADH ratio in the 2026 oxidative-stress musculoskeletal-cell experiments.","subject":{"id":"6d70addf-e302-5605-9c6a-02358209c876","slug":"nmn-apigenin-combination-2026","display_name":"NMN plus apigenin preparation in the 2026 musculoskeletal study","entity_type_key":"chemical_species"},"object":{"id":"6fe789f0-efb9-5d2c-b43a-9d705a5da004","slug":"cellular-nad-ratio","display_name":"Cellular NAD+/NADH ratio","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"67f6547a-3034-5df8-8fdd-f0ff1e6e1e92","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-nmn-cell-nad-event","event_type":"experimental_observation","label":"NMN plus apigenin increased NAD+ and the NAD+/NADH ratio in the 2026 oxidative-stress musculoskeletal-cell experiments.","description":"### api-nmn-cell-nad\n\nNMN plus apigenin increased NAD+ and the NAD+/NADH ratio in the 2026 oxidative-stress musculoskeletal-cell experiments.\nMain-text figures reviewed; exact supplementary doses not verified. A combination outperforming each component is not by itself a formal interaction test.\nModel and exposure: Three precursor-cell models under tert-butyl hydroperoxide stress; combined and single-component comparisons.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration. | 2026 | https://pubmed.ncbi.nlm.nih.gov/41944220/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC13054677/ | https://doi.org/10.1111/acel.70468 | Access: Primary main-text Results and figure descriptions reviewed. Detailed supporting Methods/supplements inaccessible; exact doses and preparation details not independently extracted.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6d70addf-e302-5605-9c6a-02358209c876","slug":"nmn-apigenin-combination-2026","display_name":"NMN plus apigenin preparation in the 2026 musculoskeletal study","entity_type_key":"chemical_species"},"role":"tested factor","stoichiometry":null,"state_label":"NMN plus apigenin during the stress model","sequence_order":0,"notes":""},{"entity":{"id":"6fe789f0-efb9-5d2c-b43a-9d705a5da004","slug":"cellular-nad-ratio","display_name":"Cellular NAD+/NADH ratio","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"measured pool","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9fbf2e03-16a9-5ca7-965c-0bfc07ca24da","slug":"nadh","display_name":"NADH","entity_type_key":"small_molecule"},"role":"ratio denominator","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary main-text Results and figure descriptions reviewed. Detailed supporting Methods/supplements inaccessible; exact doses and preparation details not independently extracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_condition","value_text":"co-administered","comparator":"Stressed controls; monotherapy comparisons also reported","unit":null,"notes":"Condition belongs to the full experimental contrast; do not separate a joint intervention.","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"experimental_condition","value_text":"co-administered","comparator":"Stressed controls; monotherapy comparisons also reported","unit":null,"notes":"Condition belongs to the full experimental contrast; do not separate a joint intervention.","entity":{"slug":"nmn","display_name":"NMN","entity_type_key":"small_molecule"}},{"dimension":"experimental_condition","value_text":"NMN plus apigenin during the stress model","comparator":"Stressed controls; monotherapy comparisons also reported","unit":null,"notes":"Condition belongs to the full experimental contrast; do not separate a joint intervention.","entity":{"slug":"nmn-apigenin-combination-2026","display_name":"NMN plus apigenin preparation in the 2026 musculoskeletal study","entity_type_key":"chemical_species"}},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"NMN plus apigenin during the stress model\", \"comparator\": \"Stressed controls; monotherapy comparisons also reported\", \"endpoint\": \"NMN plus apigenin increased NAD+ and the NAD+/NADH ratio in the 2026 oxidative-stress musculoskeletal-cell experiments.\", \"effect_direction\": \"increase\", \"combination\": \"joint\", \"conditions\": [{\"entity_slug\": \"nmn-apigenin-combination-2026\", \"state\": \"NMN plus apigenin during the stress model\"}, {\"entity_slug\": \"nmn\", \"state\": \"co-administered\"}, {\"entity_slug\": \"apigenin\", \"state\": \"co-administered\"}]}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; recorded from source.","entity":null},{"dimension":"experimental_model","value_text":"Three precursor-cell models under tert-butyl hydroperoxide stress; combined and single-component comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Apigenin collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"NMN plus apigenin increased NAD+ and the NAD+/NADH ratio in the 2026 oxidative-stress musculoskeletal-cell experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration. | https://pubmed.ncbi.nlm.nih.gov/41944220/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC13054677/ | https://doi.org/10.1111/acel.70468","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference api-nmn-cell-nad; Main-text figures reviewed; exact supplementary doses not verified. A combination outperforming each component is not by itself a formal interaction test.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f04ec184-4451-5a26-9f3b-a76feb87910c","evidence_kind":"source_excerpt","locator":"Lines 524-530","start_line":524,"end_line":530,"excerpt":"### api-nmn-cell-nad\n\nNMN plus apigenin increased NAD+ and the NAD+/NADH ratio in the 2026 oxidative-stress musculoskeletal-cell experiments.\nMain-text figures reviewed; exact supplementary doses not verified. A combination outperforming each component is not by itself a formal interaction test.\nModel and exposure: Three precursor-cell models under tert-butyl hydroperoxide stress; combined and single-component comparisons.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration. | 2026 | https://pubmed.ncbi.nlm.nih.gov/41944220/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC13054677/ | https://doi.org/10.1111/acel.70468 | Access: Primary main-text Results and figure descriptions reviewed. Detailed supporting Methods/supplements inaccessible; exact doses and preparation details not independently extracted.","model_system":"Three precursor-cell models under tert-butyl hydroperoxide stress; combined and single-component comparisons.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. 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