{"id":"61e88886-69df-5ed7-b0ae-e38855477359","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:oral-nattokinase-raises-circulating-irisin-in-rat","predicate":"increases","statement":"Nattokinase increased peripheral blood irisin in rat stroke models, and the authors place this on the path to improved neurogenesis and cognition.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"ffafdba4-0da1-5952-a384-d1ed7ae43232","mechanism_event_label":"Nattokinase increased peripheral blood irisin in rat stroke models, and the authors place this on the path to improved neurogenesis and cognition.","subject":{"id":"6b03a125-209a-5060-8b35-ec9e0e54033c","slug":"nattokinase","display_name":"Nattokinase / subtilisin NAT","entity_type_key":"peptide"},"object":{"id":"b0ffa3c4-f6cb-5fd1-a251-bb576d6d6a24","slug":"irisin","display_name":"Irisin","entity_type_key":"peptide"},"evidence_count":1,"mechanism_event":{"id":"ffafdba4-0da1-5952-a384-d1ed7ae43232","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:oral-nattokinase-raises-circulating-irisin-in-rat-event","event_type":"observed_intervention","label":"Nattokinase increased peripheral blood irisin in rat stroke models, and the authors place this on the path to improved neurogenesis and cognition.","description":"Peripheral blood and hippocampus, post-stroke","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6b03a125-209a-5060-8b35-ec9e0e54033c","slug":"nattokinase","display_name":"Nattokinase / subtilisin NAT","entity_type_key":"peptide"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b0ffa3c4-f6cb-5fd1-a251-bb576d6d6a24","slug":"irisin","display_name":"Irisin","entity_type_key":"peptide"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. 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