{"id":"6154b431-0d9e-5265-9320-c21d5ee79ee2","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-early-window","predicate":"improves_trial_measure","statement":"Five weeks of a six-hour early eating window improved insulin sensitivity without weight loss.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d78b50bd-ef13-5918-b66e-415614e4e543","mechanism_event_label":"Meal timing can affect glucose control without a multi-day fast.","subject":{"id":"7bd07a7d-ad9b-544e-8466-8afbfc4ebef1","slug":"early-time-restricted-feeding","display_name":"Early time-restricted feeding","entity_type_key":"cellular_process"},"object":{"id":"27ddfa39-1d00-5f28-bca6-da6a99618bb5","slug":"systemic-insulin-sensitivity","display_name":"Systemic insulin sensitivity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d78b50bd-ef13-5918-b66e-415614e4e543","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-early-window-event","event_type":"observed_relationship","label":"Meal timing can affect glucose control without a multi-day fast.","description":"Five weeks of a six-hour early eating window improved insulin sensitivity without weight loss.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7bd07a7d-ad9b-544e-8466-8afbfc4ebef1","slug":"early-time-restricted-feeding","display_name":"Early time-restricted feeding","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"27ddfa39-1d00-5f28-bca6-da6a99618bb5","slug":"systemic-insulin-sensitivity","display_name":"Systemic insulin sensitivity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled crossover in men with prediabetes; dinner before 3 pm versus a 12-hour window.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Early circadian timing and fasting duration were changed together.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"Meal timing can affect glucose control without a multi-day fast.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29754952/ · DOI 10.1016/j.cmet.2018.04.010","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5fec8625-f3f7-5bab-ba72-81ad542c6932","evidence_kind":"source_excerpt","locator":"Lines 424-430","start_line":424,"end_line":430,"excerpt":"## fast-early-window\nMeal timing can affect glucose control without a multi-day fast.\nFive weeks of a six-hour early eating window improved insulin sensitivity without weight loss.\nModel: Controlled crossover in men with prediabetes; dinner before 3 pm versus a 12-hour window.\nLimitations: Early circadian timing and fasting duration were changed together.\nEvidence access: Primary abstract\nEarly Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29754952/ · DOI 10.1016/j.cmet.2018.04.010","model_system":"Controlled crossover in men with prediabetes; dinner before 3 pm versus a 12-hour window.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}