{"id":"61011f27-bc3e-5304-ba48-52c740a2d23c","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-ugt-metabolism","predicate":"reported_relationship","statement":"The microsomal UGT system showed higher capacity and lower apparent affinity for RA metabolism than the phase-I system.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"f74dc9aa-3752-5703-8e9b-ba904cd85eaf","mechanism_event_label":"The microsomal UGT system showed higher capacity and lower apparent affinity for RA metabolism than the phase-I system.","subject":{"id":"4b026190-fcdb-5114-9ba5-feee5abb2f96","slug":"human-ugt-ra-metabolism","display_name":"Human UGT-dependent RA metabolism","entity_type_key":"cellular_process"},"object":{"id":"6072a4ae-d563-5466-a1b2-6d280255d346","slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"f74dc9aa-3752-5703-8e9b-ba904cd85eaf","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-ugt-metabolism-event","event_type":"experimental_observation","label":"The microsomal UGT system showed higher capacity and lower apparent affinity for RA metabolism than the phase-I system.","description":"### ra-ugt-metabolism\n\nThe microsomal UGT system showed higher capacity and lower apparent affinity for RA metabolism than the phase-I system.\nSpecific recombinant enzymes supported RA disappearance; assay kinetics do not predict a clinical drug interaction alone.\nModel and exposure: Concentration-dependent human liver microsome assays.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Metabolic interactions of rosmarinic acid with human cytochrome P450 monooxygenases and uridine diphosphate glucuronosyltransferases. | 2019 | https://pubmed.ncbi.nlm.nih.gov/30466000/ | https://doi.org/10.1016/j.biopha.2018.11.040 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4b026190-fcdb-5114-9ba5-feee5abb2f96","slug":"human-ugt-ra-metabolism","display_name":"Human UGT-dependent RA metabolism","entity_type_key":"cellular_process"},"role":"recorded factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"6072a4ae-d563-5466-a1b2-6d280255d346","slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""},{"entity":{"id":"a54855e7-1ba5-5d14-8c14-70f06248ae5a","slug":"ugt1a1","display_name":"Human UDP-glucuronosyltransferase 1A1 / UGT1A1","entity_type_key":"protein"},"role":"tested recombinant isozyme","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"09ec2e07-d2b8-5e91-a3ed-d09f0bee484a","slug":"ugt1a6","display_name":"Human UDP-glucuronosyltransferase 1A6 / UGT1A6","entity_type_key":"protein"},"role":"tested recombinant isozyme","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"378c5c60-8f7e-573e-9ac4-138722c2161e","slug":"ugt2b7","display_name":"Human UDP-glucuronosyltransferase 2B7 / UGT2B7","entity_type_key":"protein"},"role":"tested recombinant isozyme","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"fea4f3f0-7c05-59a2-9332-445b9d4f8fb0","slug":"udp-glucuronic-acid","display_name":"UDP-glucuronic acid","entity_type_key":"small_molecule"},"role":"conjugation donor","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Concentration-dependent human liver microsome assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Rosmarinic acid collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The microsomal UGT system showed higher capacity and lower apparent affinity for RA metabolism than the phase-I system.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Metabolic interactions of rosmarinic acid with human cytochrome P450 monooxygenases and uridine diphosphate glucuronosyltransferases. | https://pubmed.ncbi.nlm.nih.gov/30466000/ | https://doi.org/10.1016/j.biopha.2018.11.040","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference ra-ugt-metabolism; Specific recombinant enzymes supported RA disappearance; assay kinetics do not predict a clinical drug interaction alone.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"42b77c6a-a608-500a-9ab7-2029948aa780","evidence_kind":"source_excerpt","locator":"Lines 201-207","start_line":201,"end_line":207,"excerpt":"### ra-ugt-metabolism\n\nThe microsomal UGT system showed higher capacity and lower apparent affinity for RA metabolism than the phase-I system.\nSpecific recombinant enzymes supported RA disappearance; assay kinetics do not predict a clinical drug interaction alone.\nModel and exposure: Concentration-dependent human liver microsome assays.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Metabolic interactions of rosmarinic acid with human cytochrome P450 monooxygenases and uridine diphosphate glucuronosyltransferases. | 2019 | https://pubmed.ncbi.nlm.nih.gov/30466000/ | https://doi.org/10.1016/j.biopha.2018.11.040 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","model_system":"Concentration-dependent human liver microsome assays.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"606cff22-a6ed-59cd-a84d-87f44c59dc25","stable_key":"import-ca8e9e6a-6953-51ec-b712-2b06398a416d","title":"Rosmarinic acid: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"684b4eab1dc2c0057f679109770af0de9340af5cd933377b590298cf8a752956","revision_id":"4028d9c5-fb17-54c5-b72c-c6d21678a832","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}