{"id":"60a3721d-b123-5e72-b191-1a01648e9914","stable_key":"research:selenoi-synthesizes-plasmanyl-pe","predicate":"synthesizes","statement":"SELENOI uses CDP-ethanolamine and alkyl-acylglycerol to produce plasmanyl-PE and CMP.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"literature_reviewed:direct_experimental","direction":"neutral","is_public":true,"mechanism_event_id":"8d5d2942-2bd3-533b-96d7-ed414bd57231","mechanism_event_label":"SELENOI also builds an ether-linked PE precursor.","subject":{"id":"8334e065-581a-5500-b664-dbe129850043","slug":"selenoi","display_name":"SELENOI","entity_type_key":"protein"},"object":{"id":"3fa1160b-a825-55ac-aa22-830517847fb0","slug":"plasmanyl-pe","display_name":"Plasmanylethanolamine","entity_type_key":"lipid"},"evidence_count":1,"mechanism_event":{"id":"8d5d2942-2bd3-533b-96d7-ed414bd57231","stable_key":"research:selenoi-synthesizes-plasmanyl-pe","event_type":"phosphotransfer","label":"SELENOI also builds an ether-linked PE precursor.","description":"SELENOI uses CDP-ethanolamine and alkyl-acylglycerol to produce plasmanyl-PE and CMP.","status":"active","compartment":null,"participants":[{"entity":{"id":"8334e065-581a-5500-b664-dbe129850043","slug":"selenoi","display_name":"SELENOI","entity_type_key":"protein"},"role":"enzyme","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"53b36ed3-4463-5621-ac99-a4e5e360f05e","slug":"cdp-ethanolamine","display_name":"CDP-ethanolamine","entity_type_key":"small_molecule"},"role":"substrate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a1d62e26-ff51-507e-83f9-2a48a21fc6e2","slug":"alkyl-acylglycerol","display_name":"AAG","entity_type_key":"lipid"},"role":"substrate","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"3fa1160b-a825-55ac-aa22-830517847fb0","slug":"plasmanyl-pe","display_name":"Plasmanylethanolamine","entity_type_key":"lipid"},"role":"product","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"729ece0d-0058-5133-a6b7-c68c304be2eb","slug":"cmp","display_name":"CMP","entity_type_key":"small_molecule"},"role":"product","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cell_type","value_text":"patient fibroblasts and HeLa","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Lipid synthesis and genetic studies","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Plasmanyl-PE is distinct from plasmenyl-PE.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"human","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"265bb193-1077-5913-a497-59b0654a4d14","evidence_kind":"curated_literature_summary","locator":"lines 738-748","start_line":738,"end_line":748,"excerpt":"## selenoi-synthesizes-plasmanyl-pe\n\nSELENOI also builds an ether-linked PE precursor.\n\nSELENOI uses CDP-ethanolamine and alkyl-acylglycerol to produce plasmanyl-PE and CMP.\n\nOrganism: human\nCell type: patient fibroblasts and HeLa\nExperimental model: Lipid synthesis and genetic studies\nLimitations: Plasmanyl-PE is distinct from plasmenyl-PE.\nPrimary reference: [EPT1 (selenoprotein I) is critical for the neural development and maintenance of plasmalogen in humans](https://pmc.ncbi.nlm.nih.gov/articles/PMC5983406/)","model_system":"Lipid synthesis and genetic studies","directness":"author_interpretation","verification_status":"secondary_verified","notes":"Curated summary; inspect the linked primary papers for original methods and results.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f892f13-06ea-5199-a33c-a703f35c80ae","stable_key":"selenium-research-2026-09-17","title":"Selenium: literature corrections and mechanism additions","document_type":"curated_literature_review","citation_label":"Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually","file_path":"","sha256":"0b818b10c1c7120e5caf7f4d4019d7bd025d745692e424f515d3ef903c9ab7f3","revision_id":"80984e03-5f0f-5877-8094-afef7637444e","review_status":"secondary_verified","notes":"Secondary curated summaries of primary experiments, with explicit models and limitations. Not archived primary full text."}}],"relations":[],"conflicts":[],"corrections":[],"research":{"topic":"ether-lipid-biosynthesis","plain_language":"SELENOI also builds an ether-linked PE precursor.","evidence_scope":"direct_experimental","papers":[{"key":"horibata-2018-ept1-lipids","title":"EPT1 (selenoprotein I) is critical for the neural development and maintenance of plasmalogen in humans","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5983406/","doi":"10.1194/jlr.P081620","year":2018,"model":"Human patient fibroblasts, HeLa gene disruption and lipid assays","summary":"Defines SELENOI-dependent phosphatidylethanolamine production and consequences for ether lipids."}]}}