{"id":"60a10943-c660-50b1-bb17-ddd22ff56e7c","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-human-beta-catenin","predicate":"promotes_nuclear_translocation","statement":"An Akt-dependent signaling cascade through CaSR promoted beta-catenin nuclear translocation in strontium-treated primary human osteoblasts.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"aad1cd58-f065-5ea8-b83c-cb624c616a85","mechanism_event_label":"A receptor signal can reach a transcriptional regulator through Akt.","subject":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"object":{"id":"79f18db5-3833-52d2-8136-94e295f4ef8a","slug":"ctnnb1","display_name":"Human beta-catenin / CTNNB1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"aad1cd58-f065-5ea8-b83c-cb624c616a85","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-human-beta-catenin-event","event_type":"observed_relationship","label":"A receptor signal can reach a transcriptional regulator through Akt.","description":"An Akt-dependent signaling cascade through CaSR promoted beta-catenin nuclear translocation in strontium-treated primary human osteoblasts.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"79f18db5-3833-52d2-8136-94e295f4ef8a","slug":"ctnnb1","display_name":"Human beta-catenin / CTNNB1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1c0d5c58-d358-5501-9bdf-8999bcf79fd4","slug":"casr","display_name":"Calcium-sensing receptor / CaSR","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"a13cb592-c939-5f92-9206-d774248802fc","slug":"akt-proteins","display_name":"AKT serine/threonine kinase family","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human primary osteoblast signaling experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not prove direct binding to Akt or beta-catenin; Akt isoform not resolved here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"A receptor signal can reach a transcriptional regulator through Akt.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"An Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21566129/ · DOI 10.1074/jbc.M111.251116","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fcc0c06e-911c-5b15-b612-82b15cf0d409","evidence_kind":"source_excerpt","locator":"Lines 182-188","start_line":182,"end_line":188,"excerpt":"## strontium-human-beta-catenin\nA receptor signal can reach a transcriptional regulator through Akt.\nAn Akt-dependent signaling cascade through CaSR promoted beta-catenin nuclear translocation in strontium-treated primary human osteoblasts.\nModel: Human primary osteoblast signaling experiments.\nLimitations: Does not prove direct binding to Akt or beta-catenin; Akt isoform not resolved here.\nEvidence access: Primary abstract\nAn Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21566129/ · DOI 10.1074/jbc.M111.251116","model_system":"Human primary osteoblast signaling experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"51221949263cdf8a22a79c32e3989599de1a37dc215700e0a076f436b40a1005","revision_id":"84f6df49-c456-5ad2-8214-cc69d5dc7722","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}