{"id":"6047c9e3-782e-5477-8413-90c1458d306c","stable_key":"b26c9d01-98fd-50d3-8f39-44db46961ee5:acetate-vinegar-body-fat","predicate":"reduces","statement":"Body weight, body mass index, visceral fat area, waist circumference and serum triglyceride levels were significantly lower in both vinegar intake groups than in the placebo group after 12 weeks.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"c1fc3cdf-f716-5b34-8be1-df2cd50bb8b2","mechanism_event_label":"Over twelve weeks, daily vinegar lowered weight, waist, visceral fat and blood triglycerides.","subject":{"id":"236303ab-c590-5e01-bace-9f2cf05fa6fa","slug":"acetic-acid","display_name":"Acetic acid","entity_type_key":"chemical_species"},"object":{"id":"524f8fb5-3ada-557c-b9b5-f8fed9e8a1a3","slug":"visceral-fat-area","display_name":"Visceral fat area","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c1fc3cdf-f716-5b34-8be1-df2cd50bb8b2","stable_key":"b26c9d01-98fd-50d3-8f39-44db46961ee5:acetate-vinegar-body-fat-event","event_type":"observed_intervention","label":"Over twelve weeks, daily vinegar lowered weight, waist, visceral fat and blood triglycerides.","description":"Body weight, body mass index, visceral fat area, waist circumference and serum triglyceride levels were significantly lower in both vinegar intake groups than in the placebo group after 12 weeks.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ad15eac6-9953-58af-b825-ce8d21901f43","slug":"serum-triglyceride-concentration","display_name":"Serum triglyceride concentration","entity_type_key":"cellular_process"},"role":"co_measured","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"236303ab-c590-5e01-bace-9f2cf05fa6fa","slug":"acetic-acid","display_name":"Acetic acid","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"524f8fb5-3ada-557c-b9b5-f8fed9e8a1a3","slug":"visceral-fat-area","display_name":"Visceral fat area","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/acetate-research/19661687.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"bcc0d712702f1a020d98a208a90656ef5429bcbfe87257559a6919d673459955\", \"start_char\": 0, \"end_char\": 884, \"text_sha256\": \"bcc0d712702f1a020d98a208a90656ef5429bcbfe87257559a6919d673459955\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind randomised trial in obese Japanese subjects over 12 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"500 ml daily of a beverage containing 15 ml vinegar (750 mg acetic acid), 30 ml vinegar (1500 mg acetic acid), or no vinegar","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The longest human exposure in this collection. A single population, and the measured endpoints are anthropometric rather than mechanistic.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion.","comparator":null,"unit":null,"notes":"","entity":{"slug":"acetic-acid","display_name":"Acetic acid","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Over twelve weeks, daily vinegar lowered weight, waist, visceral fat and blood triglycerides.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[acetate-p19661687] Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects. (2009). https://pubmed.ncbi.nlm.nih.gov/19661687/ DOI: 10.1271/bbb.90231","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole body","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4be51f0d-1f91-5f45-8c33-c1f1deb9929b","evidence_kind":"source_excerpt","locator":"Lines 199-210","start_line":199,"end_line":210,"excerpt":"### acetate-vinegar-body-fat\nBody weight, body mass index, visceral fat area, waist circumference and serum triglyceride levels were significantly lower in both vinegar intake groups than in the placebo group after 12 weeks.\nCondition category: normal\nnutrient_topic: Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion.\nplain_language: Over twelve weeks, daily vinegar lowered weight, waist, visceral fat and blood triglycerides.\norganism: Human\ntissue_or_cell_type: Whole body\nexperimental_model: Double-blind randomised trial in obese Japanese subjects over 12 weeks\nlimitations: The longest human exposure in this collection. A single population, and the measured endpoints are anthropometric rather than mechanistic.\nexposure: 500 ml daily of a beverage containing 15 ml vinegar (750 mg acetic acid), 30 ml vinegar (1500 mg acetic acid), or no vinegar\nevidence_span: {\"source_cache\": \"artifacts/acetate-research/19661687.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"bcc0d712702f1a020d98a208a90656ef5429bcbfe87257559a6919d673459955\", \"start_char\": 0, \"end_char\": 884, \"text_sha256\": \"bcc0d712702f1a020d98a208a90656ef5429bcbfe87257559a6919d673459955\"}\n[acetate-p19661687] Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects. 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