{"id":"60169a2d-5e8e-52fe-928b-ba26742f2e11","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-salt-eae","predicate":"high_salt_diet_increases","statement":"Mice fed a high-salt diet developed more severe experimental autoimmune encephalomyelitis.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a5375399-5990-56c7-b275-e365818ac1a8","mechanism_event_label":"The cell findings had a disease-model counterpart in mice; human disease causation remains unproven.","subject":{"id":"f3fe99b8-4e4a-57cd-9a86-3651092c9f6c","slug":"sodium-chloride","display_name":"Sodium chloride","entity_type_key":"chemical_species"},"object":{"id":"8d2bf9b2-c146-5767-8521-f0c081d2ab60","slug":"mouse-eae-severity","display_name":"Experimental autoimmune encephalomyelitis severity in mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a5375399-5990-56c7-b275-e365818ac1a8","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-salt-eae-event","event_type":"observed_intervention","label":"The cell findings had a disease-model counterpart in mice; human disease causation remains unproven.","description":"Mice fed a high-salt diet developed more severe experimental autoimmune encephalomyelitis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f3fe99b8-4e4a-57cd-9a86-3651092c9f6c","slug":"sodium-chloride","display_name":"Sodium chloride","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8d2bf9b2-c146-5767-8521-f0c081d2ab60","slug":"mouse-eae-severity","display_name":"Experimental autoimmune encephalomyelitis severity in mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/sodium-research/23467095.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d16bb4b4becde85238492e01054f360aeaf57ea90015cba99459cd155fa4251f\", \"start_char\": 0, \"end_char\": 1913, \"text_sha256\": \"d16bb4b4becde85238492e01054f360aeaf57ea90015cba99459cd155fa4251f\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cytokine-driven T-cell culture, gene silencing/inhibition and experimental autoimmune encephalomyelitis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Increased NaCl in culture or high-salt mouse diet","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"NaCl exposure includes both ions and osmotic context. Mouse EAE and cultured T cells do not establish that salt causes human multiple sclerosis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sodium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human and mouse T cells; mouse disease model","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The cell findings had a disease-model counterpart in mice; human disease causation remains unproven.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sodium-p23467095] Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. (2013). https://pubmed.ncbi.nlm.nih.gov/23467095/ DOI: 10.1038/nature11868","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"T-helper cells and experimental CNS autoimmunity","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"67cb9dcf-4577-59b1-8ceb-586d1db0fece","evidence_kind":"source_excerpt","locator":"Lines 538-549","start_line":538,"end_line":549,"excerpt":"### sodium-salt-eae\nMice fed a high-salt diet developed more severe experimental autoimmune encephalomyelitis.\nCondition category: normal\nnutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The cell findings had a disease-model counterpart in mice; human disease causation remains unproven.\norganism: Human and mouse T cells; mouse disease model\ntissue_or_cell_type: T-helper cells and experimental CNS autoimmunity\nexperimental_model: Cytokine-driven T-cell culture, gene silencing/inhibition and experimental autoimmune encephalomyelitis\nlimitations: NaCl exposure includes both ions and osmotic context. Mouse EAE and cultured T cells do not establish that salt causes human multiple sclerosis.\nexposure: Increased NaCl in culture or high-salt mouse diet\nevidence_span: {\"source_cache\": \"artifacts/sodium-research/23467095.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d16bb4b4becde85238492e01054f360aeaf57ea90015cba99459cd155fa4251f\", \"start_char\": 0, \"end_char\": 1913, \"text_sha256\": \"d16bb4b4becde85238492e01054f360aeaf57ea90015cba99459cd155fa4251f\"}\n[sodium-p23467095] Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. (2013). https://pubmed.ncbi.nlm.nih.gov/23467095/ DOI: 10.1038/nature11868","model_system":"Cytokine-driven T-cell culture, gene silencing/inhibition and experimental autoimmune encephalomyelitis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [sodium-p23467095] Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. (2013). https://pubmed.ncbi.nlm.nih.gov/23467095/ DOI: 10.1038/nature11868","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c260cd7b-beb0-5113-a198-69ec8fd4492c","stable_key":"import-195e8b84-ca5a-591a-a045-c55c53c8a01c","title":"Sodium: gradients, nutrient transport, fluid regulation and loss states (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"684f65cf0661c18395831ade4b02bb24d5e66c568f0d00a3471600eaf5d4d1c6","revision_id":"39866f04-3052-5f59-bd95-6806c5490875","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}