{"id":"6009572e-6622-5a2d-9d24-a7aa1f6f7b8b","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:nattokinase-lowers-the-nlrp3-inflammasome","predicate":"reduces","statement":"Nattokinase inhibited NLRP3 inflammasome formation in endothelial cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"4bbfbf6f-88b0-58e1-ad90-e29759758212","mechanism_event_label":"Nattokinase inhibited NLRP3 inflammasome formation in endothelial cells.","subject":{"id":"6b03a125-209a-5060-8b35-ec9e0e54033c","slug":"nattokinase","display_name":"Nattokinase / subtilisin NAT","entity_type_key":"peptide"},"object":{"id":"a732d76c-af99-5440-b172-400274462345","slug":"nlrp3-inflammasome","display_name":"NLRP3 inflammasome","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"4bbfbf6f-88b0-58e1-ad90-e29759758212","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:nattokinase-lowers-the-nlrp3-inflammasome-event","event_type":"biochemical_relationship","label":"Nattokinase inhibited NLRP3 inflammasome formation in endothelial cells.","description":"Cultured endothelium","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6b03a125-209a-5060-8b35-ec9e0e54033c","slug":"nattokinase","display_name":"Nattokinase / subtilisin NAT","entity_type_key":"peptide"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a732d76c-af99-5440-b172-400274462345","slug":"nlrp3-inflammasome","display_name":"NLRP3 inflammasome","entity_type_key":"protein_complex"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Endothelial cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Nattokinase","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Placed downstream of autophagy induction by the necessity experiments rather than measured as an independent arm.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Endothelial cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Nattokinase inhibited NLRP3 inflammasome formation in endothelial cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Nattokinase attenuates endothelial inflammation through the activation of SRF and THBS1. (2024) https://pubmed.ncbi.nlm.nih.gov/38679250/ DOI: 10.1016/j.ijbiomac.2024.131779","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Cultured endothelium","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0e8a86a5-7427-59b9-a03f-e70b57b25e19","evidence_kind":"source_excerpt","locator":"Lines 631-631","start_line":631,"end_line":631,"excerpt":"Nattokinase inhibited NLRP3 inflammasome formation in endothelial cells.","model_system":"Endothelial cells","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"41cb127c-1c23-53aa-b7d0-5ec7f6fa3c99","stable_key":"import-33bef151-bdc7-5892-aff6-0345ab149739","title":"Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23)","document_type":"imported_text","citation_label":"Original AI-assisted curation built from a supplied entity-first document of 105 entities and 129 claims. Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. Not publisher full text.","file_path":"","sha256":"34fc46e0e849d06bfa13cb099a79b50679dd6fd0de8a5a0575326afdde3259c1","revision_id":"efd063e6-e982-5f6e-a4b8-6f2ffe4185ce","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}