{"id":"5fffb2ca-572d-5195-8dc4-bd0691824737","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-sporo-cure","predicate":"associated_with","statement":"In 57 randomized patients, cure was 89.6% with once-daily versus 89.2% with three-times-daily SSKI.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6f87ca2f-b166-54b6-a96a-efe7a3c9018c","mechanism_event_label":"Clinical use against a skin fungal infection extends beyond the thyroid.","subject":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"object":{"id":"a8653dd0-9bdd-565a-a681-267d6449dd88","slug":"cutaneous-sporotrichosis-cure","display_name":"Clinical cure of cutaneous sporotrichosis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6f87ca2f-b166-54b6-a96a-efe7a3c9018c","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-sporo-cure-event","event_type":"observed_relationship","label":"Clinical use against a skin fungal infection extends beyond the thyroid.","description":"In 57 randomized patients, cure was 89.6% with once-daily versus 89.2% with three-times-daily SSKI.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a8653dd0-9bdd-565a-a681-267d6449dd88","slug":"cutaneous-sporotrichosis-cure","display_name":"Clinical cure of cutaneous sporotrichosis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Culture-confirmed cutaneous sporotrichosis; open-label schedule comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Both groups received SSKI; no untreated comparator and no mechanism isolated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Clinical use against a skin fungal infection extends beyond the thyroid.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Treatment of cutaneous sporotrichosis with one daily dose of potassium iodide. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8866807/ · DOI 10.1097/00006454-199604000-00014","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9839cb5a-8410-5f50-a1fa-0c51ad7ce27a","evidence_kind":"source_excerpt","locator":"Lines 432-438","start_line":432,"end_line":438,"excerpt":"## ki-sporo-cure\nClinical use against a skin fungal infection extends beyond the thyroid.\nIn 57 randomized patients, cure was 89.6% with once-daily versus 89.2% with three-times-daily SSKI.\nModel: Culture-confirmed cutaneous sporotrichosis; open-label schedule comparison.\nLimitations: Both groups received SSKI; no untreated comparator and no mechanism isolated.\nEvidence location: Primary abstract\nTreatment of cutaneous sporotrichosis with one daily dose of potassium iodide. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8866807/ · DOI 10.1097/00006454-199604000-00014","model_system":"Culture-confirmed cutaneous sporotrichosis; open-label schedule comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text.","file_path":"","sha256":"3ff9da818dd7a763a59c6abcff2eaee136d7f887a777034feaa5ba304a8fa6ce","revision_id":"53f2ae88-8a91-5326-ac49-3bb510ca78c3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}