{"id":"5ff07ab5-ff5c-5483-a0d0-5f6d96cff670","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-creatine-torque","predicate":"attenuates_creatine_response","statement":"Creatine increased dynamic torque by 10–23%, whereas the creatine-plus-caffeine regimen did not improve torque.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"f121d9b7-ec13-5bef-ad68-eade36752c42","mechanism_event_label":"The same stored-energy increase did not guarantee the same performance response.","subject":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"object":{"id":"ffb91f4e-856d-5373-9100-12cb654e61f1","slug":"intermittent-knee-extensor-torque","display_name":"Torque during intermittent knee-extensor exercise","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f121d9b7-ec13-5bef-ad68-eade36752c42","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-creatine-torque-event","event_type":"observed_relationship","label":"The same stored-energy increase did not guarantee the same performance response.","description":"Creatine increased dynamic torque by 10–23%, whereas the creatine-plus-caffeine regimen did not improve torque.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ffb91f4e-856d-5373-9100-12cb654e61f1","slug":"intermittent-knee-extensor-torque","display_name":"Torque during intermittent knee-extensor exercise","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Nine healthy men; six-day creatine loading 0.5 g/kg/day, with or without caffeine 5 mg/kg/day; intermittent knee-extensor testing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small protocol-specific trial. Creatine accumulation and performance were separate endpoints.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The same stored-energy increase did not guarantee the same performance response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Caffeine counteracts the ergogenic action of muscle creatine loading. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8929583/ · DOI 10.1152/jappl.1996.80.2.452","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3b615c92-8e10-53e4-aa00-b8dc89fb57f3","evidence_kind":"source_excerpt","locator":"Lines 452-458","start_line":452,"end_line":458,"excerpt":"## caf-creatine-torque\nThe same stored-energy increase did not guarantee the same performance response.\nCreatine increased dynamic torque by 10–23%, whereas the creatine-plus-caffeine regimen did not improve torque.\nModel: Nine healthy men; six-day creatine loading 0.5 g/kg/day, with or without caffeine 5 mg/kg/day; intermittent knee-extensor testing.\nLimitations: Small protocol-specific trial. Creatine accumulation and performance were separate endpoints.\nEvidence access: Primary abstract\nCaffeine counteracts the ergogenic action of muscle creatine loading. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8929583/ · DOI 10.1152/jappl.1996.80.2.452","model_system":"Nine healthy men; six-day creatine loading 0.5 g/kg/day, with or without caffeine 5 mg/kg/day; intermittent knee-extensor testing.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"780d73d4abd45a0284d2cc0c646dbe8432ae347362891a4b98a19a61341a7325","revision_id":"f36ffb0a-d6df-522f-b783-5e30214b9e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}