{"id":"5f6f5253-29fa-5a55-850a-edd4fbe540d6","stable_key":"49fecf36-4958-5f15-8c78-9a68cba50763:capsaicin-fat-oxidation","predicate":"maintains","statement":"In a randomized crossover trial, capsaicin maintained postprandial fat oxidation above placebo during the 90-minute observation period.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"f6d588fa-eb5d-591f-b6f1-7aaf92678365","mechanism_event_label":"In a randomized crossover trial, capsaicin maintained postprandial fat oxidation above placebo during the 90-minute observation period.","subject":{"id":"9cdd3a64-5185-5998-82a6-d25c8409b998","slug":"capsaicin","display_name":"Capsaicin","entity_type_key":"small_molecule"},"object":{"id":"d5f07c67-430c-53f5-b856-18340901c16f","slug":"human-postprandial-fat-oxidation","display_name":"Human postprandial fat oxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f6d588fa-eb5d-591f-b6f1-7aaf92678365","stable_key":"49fecf36-4958-5f15-8c78-9a68cba50763:capsaicin-fat-oxidation-event","event_type":"observed_relationship","label":"In a randomized crossover trial, capsaicin maintained postprandial fat oxidation above placebo during the 90-minute observation period.","description":"In a randomized crossover trial, capsaicin maintained postprandial fat oxidation above placebo during the 90-minute observation period.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9cdd3a64-5185-5998-82a6-d25c8409b998","slug":"capsaicin","display_name":"Capsaicin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d5f07c67-430c-53f5-b856-18340901c16f","slug":"human-postprandial-fat-oxidation","display_name":"Human postprandial fat oxidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Oral capsaicin arm versus placebo and other flavor agonists","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"90 minutes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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(2016). https://pubmed.ncbi.nlm.nih.gov/26883089/ DOI: 10.1038/srep20795","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Indirect calorimetry and autonomic measures","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fcc8d689-81e8-5557-a81b-d467c69de52e","evidence_kind":"source_excerpt","locator":"Lines 99-108","start_line":99,"end_line":108,"excerpt":"## capsaicin-fat-oxidation\nIn a randomized crossover trial, capsaicin maintained postprandial fat oxidation above placebo during the 90-minute observation period.\nModel/species: Healthy human participants\nTissue/system: Indirect calorimetry and autonomic measures\nExposure: Oral capsaicin arm versus placebo and other flavor agonists\nRoute: Oral\nDuration: 90 minutes\nLimits: Energy expenditure increased after cinnamaldehyde, not specifically after capsaicin in the reported abstract; the capsaicin dose was judged sensorially intense.\nPrimary reference: Effects of TRP channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects. (2016). https://pubmed.ncbi.nlm.nih.gov/26883089/ DOI: 10.1038/srep20795\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Healthy human participants","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"883c8afb-af48-5561-ae3b-00d4f3c26752","stable_key":"import-49fecf36-4958-5f15-8c78-9a68cba50763","title":"Capsaicin: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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