{"id":"5f582ee7-8265-57a5-b9ec-378ee67a2e9c","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-no-markers-null","predicate":"did_not_significantly_change","statement":"The measured NO-status markers were not significantly changed.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"43961673-30ea-5d9f-b672-57d822140e8e","mechanism_event_label":"The blood-pressure result does not prove increased nitric oxide.","subject":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"object":{"id":"58fc52a1-4767-5be5-9613-9f404fba34ed","slug":"nitric-oxide-status-markers","display_name":"Measured human nitric-oxide status markers","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"43961673-30ea-5d9f-b672-57d822140e8e","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-no-markers-null-event","event_type":"observed_intervention","label":"The blood-pressure result does not prove increased nitric oxide.","description":"The measured NO-status markers were not significantly changed.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"58fc52a1-4767-5be5-9613-9f404fba34ed","slug":"nitric-oxide-status-markers","display_name":"Measured human nitric-oxide status markers","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chlorogenic_acid-research/22900702.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f3cf1535535a14d11902c63d1f0be28faf07b80835cf5f1b296a62cc2e78e1b1\", \"start_char\": 0, \"end_char\": 1044, \"text_sha256\": \"f3cf1535535a14d11902c63d1f0be28faf07b80835cf5f1b296a62cc2e78e1b1\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled acute crossover in 23 adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"400 mg chlorogenic acid; study product naming retained","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A small acute surrogate-endpoint study, not cardiovascular event prevention. Later literature describes the product with a 3-CQA label; historical numbering must be checked before treating it as modern neochlorogenic acid.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The blood-pressure result does not prove increased nitric oxide.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chlorogenic_acid-p22900702] Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial. (2012). https://pubmed.ncbi.nlm.nih.gov/22900702/ DOI: 10.1021/jf303440j","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood pressure, endothelial function and NO-related markers","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cf61f76f-5488-5f4b-8ba5-86b1db1d1034","evidence_kind":"source_excerpt","locator":"Lines 932-943","start_line":932,"end_line":943,"excerpt":"### chlorogenic_acid-no-markers-null\nThe measured NO-status markers were not significantly changed.\nCondition category: normal\nnutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The blood-pressure result does not prove increased nitric oxide.\norganism: Human\ntissue_or_cell_type: Blood pressure, endothelial function and NO-related markers\nexperimental_model: Randomized double-blind placebo-controlled acute crossover in 23 adults\nlimitations: A small acute surrogate-endpoint study, not cardiovascular event prevention. Later literature describes the product with a 3-CQA label; historical numbering must be checked before treating it as modern neochlorogenic acid.\nexposure: 400 mg chlorogenic acid; study product naming retained\nevidence_span: {\"source_cache\": \"artifacts/chlorogenic_acid-research/22900702.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f3cf1535535a14d11902c63d1f0be28faf07b80835cf5f1b296a62cc2e78e1b1\", \"start_char\": 0, \"end_char\": 1044, \"text_sha256\": \"f3cf1535535a14d11902c63d1f0be28faf07b80835cf5f1b296a62cc2e78e1b1\"}\n[chlorogenic_acid-p22900702] Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial. 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