{"id":"5f396423-99ff-584a-882e-62524fe3d339","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-metabolic-endpoint","predicate":"resists_further_conversion_in","statement":"Steviol at 0.08 or 0.2 mg/mL showed no detected degradation over 24 hours in pooled anaerobic fecal homogenates from five volunteers.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"097bc9bd-164d-529c-a25a-1ba9b4588c01","mechanism_event_label":"The gut conversion endpoint is not necessarily the same as the liver endpoint.","subject":{"id":"8ba32fe6-183f-5cd5-b386-02e6440e78a0","slug":"steviol","display_name":"Steviol","entity_type_key":"small_molecule"},"object":{"id":"98f51c8f-4962-513b-be3b-e24036f00800","slug":"human-fecal-steviol-incubation","display_name":"Human fecal steviol incubation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"097bc9bd-164d-529c-a25a-1ba9b4588c01","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-metabolic-endpoint-event","event_type":"observed_relationship","label":"The gut conversion endpoint is not necessarily the same as the liver endpoint.","description":"Steviol at 0.08 or 0.2 mg/mL showed no detected degradation over 24 hours in pooled anaerobic fecal homogenates from five volunteers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8ba32fe6-183f-5cd5-b386-02e6440e78a0","slug":"steviol","display_name":"Steviol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"98f51c8f-4962-513b-be3b-e24036f00800","slug":"human-fecal-steviol-incubation","display_name":"Human fecal steviol incubation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Pooled human fecal material; LC/MS/ESI.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No detected degradation under these conditions does not mean steviol is universally inert.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The gut conversion endpoint is not necessarily the same as the liver endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12504168/ · DOI 10.1016/s0278-6915(02)00235-1","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"96d1fc0f-a852-56de-931b-e5a957855b52","evidence_kind":"source_excerpt","locator":"Lines 42-48","start_line":42,"end_line":48,"excerpt":"## stevia-metabolic-endpoint\nThe gut conversion endpoint is not necessarily the same as the liver endpoint.\nSteviol at 0.08 or 0.2 mg/mL showed no detected degradation over 24 hours in pooled anaerobic fecal homogenates from five volunteers.\nModel: Pooled human fecal material; LC/MS/ESI.\nLimitations: No detected degradation under these conditions does not mean steviol is universally inert.\nEvidence access: Primary abstract\nIn vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12504168/ · DOI 10.1016/s0278-6915(02)00235-1","model_system":"Pooled human fecal material; LC/MS/ESI.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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