{"id":"5ec2ae62-d507-525c-ad1e-bc631fe0f507","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:hsv-recurrence-null-trial","predicate":"did_not_reduce_overall","statement":"The 1980 crossover trial found no overall reduction in herpes-labialis recurrence or healing time with 1 g daily lysine, despite more recurrence-free participants.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"dfdf9e32-8c15-5fec-bd3d-723a929b5e7c","mechanism_event_label":"The average recurrence and healing results were negative, although one secondary pattern favored treatment.","subject":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"object":{"id":"b1dda601-270a-5a8a-ad62-565e1d4d61d7","slug":"hsv-recurrence","display_name":"Recurrent herpes simplex episodes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"dfdf9e32-8c15-5fec-bd3d-723a929b5e7c","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:hsv-recurrence-null-trial-event","event_type":"observed_intervention","label":"The average recurrence and healing results were negative, although one secondary pattern favored treatment.","description":"The 1980 crossover trial found no overall reduction in herpes-labialis recurrence or healing time with 1 g daily lysine, despite more recurrence-free participants.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b1dda601-270a-5a8a-ad62-565e1d4d61d7","slug":"hsv-recurrence","display_name":"Recurrent herpes simplex episodes","entity_type_key":"cellular_process"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6a3c02ea-ba75-53a7-ba2c-846a4596ec31","slug":"herpes-lesion-healing","display_name":"Herpes lesion healing","entity_type_key":"cellular_process"},"role":"no_observed_benefit","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Double-blind crossover clinical trial in 65 patients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Twelve-week treatment periods; outcome definition and regimen differ from the later positive trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The average recurrence and healing results were negative, although one secondary pattern favored treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[milman1980] Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. (1980). https://medicaljournalssweden.se/actadv/article/view/10630 DOI: 10.2340/00015555608587","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Lip herpes lesions","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d00a6613-ec0a-5448-abe3-bed303a43b88","evidence_kind":"source_excerpt","locator":"Lines 679-687","start_line":679,"end_line":687,"excerpt":"### hsv-recurrence-null-trial\nThe 1980 crossover trial found no overall reduction in herpes-labialis recurrence or healing time with 1 g daily lysine, despite more recurrence-free participants.\nPlain language: The average recurrence and healing results were negative, although one secondary pattern favored treatment.\nCondition category: normal\norganism: Homo sapiens\ntissue_or_cell_type: Lip herpes lesions\nexperimental_model: Double-blind crossover clinical trial in 65 patients\nlimitations: Twelve-week treatment periods; outcome definition and regimen differ from the later positive trial.\n[milman1980] Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. (1980). https://medicaljournalssweden.se/actadv/article/view/10630 DOI: 10.2340/00015555608587","model_system":"Double-blind crossover clinical trial in 65 patients","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [milman1980] Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. (1980). https://medicaljournalssweden.se/actadv/article/view/10630 DOI: 10.2340/00015555608587","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93998d47c21525409ba82f1c82ededf2893dff15fbe61c7deffc175b0e298e97","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[{"id":"fdec7279-4b92-575a-be3f-04976742f292","title":"Lysine supplementation has inconsistent HSV trial results","kind":"qualification","status":"open","why":"These are inconsistent clinical findings, not logically contradictory molecular results. Regimen, duration, population, design, and endpoints differ. They cannot establish a dose threshold or explain the discrepancy.","resolution":"Unresolved; needs review.","created_at":"2026-09-17 07:46:03","record_type":"conflict","display_label":"Recorded conflict","record_url":"/conflicts/fdec7279-4b92-575a-be3f-04976742f292","sides":[{"conflict_id":"fdec7279-4b92-575a-be3f-04976742f292","ordinal":0,"label":"Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis.","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","start_line":669,"end_line":677,"quote":"### hsv-recurrence-positive-trial\nThe 1987 trial reported fewer recurrent HSV episodes with lysine than placebo among completers receiving 1 g three times daily for six months.\nPlain language: One small trial favored lysine for recurrence prevention.\nCondition category: normal\norganism: Homo sapiens\ntissue_or_cell_type: Clinical mucocutaneous HSV outcomes\nexperimental_model: Double-blind placebo-controlled multicenter clinical trial\nlimitations: 52 completers; reported symptom/healing findings do not prove direct viral inhibition; intake is a studied regimen, not a recommendation.\n[griffith1987] Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. (1987). https://pubmed.ncbi.nlm.nih.gov/3115841/ DOI: 10.1159/000248823","source_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","source_title":"L-Lysine: mechanism-first literature curation (2026-09-17)","claim_ids":["f2f5bf41-b0ca-580e-b68c-ecbfb402e57b"]},{"conflict_id":"fdec7279-4b92-575a-be3f-04976742f292","ordinal":1,"label":"Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study.","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","start_line":679,"end_line":687,"quote":"### hsv-recurrence-null-trial\nThe 1980 crossover trial found no overall reduction in herpes-labialis recurrence or healing time with 1 g daily lysine, despite more recurrence-free participants.\nPlain language: The average recurrence and healing results were negative, although one secondary pattern favored treatment.\nCondition category: normal\norganism: Homo sapiens\ntissue_or_cell_type: Lip herpes lesions\nexperimental_model: Double-blind crossover clinical trial in 65 patients\nlimitations: Twelve-week treatment periods; outcome definition and regimen differ from the later positive trial.\n[milman1980] Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. (1980). https://medicaljournalssweden.se/actadv/article/view/10630 DOI: 10.2340/00015555608587","source_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","source_title":"L-Lysine: mechanism-first literature curation (2026-09-17)","claim_ids":["5ec2ae62-d507-525c-ad1e-bc631fe0f507"]}]}],"corrections":[],"research":null}