{"id":"5e8bc67f-bc97-5848-8220-f25e9219a727","stable_key":"56f1d914-e7da-595a-af69-c217b2b47407:l-phenylalanine-renal-transporter","predicate":"transports","statement":"B0AT1/SLC6A19 transports neutral amino acids including phenylalanine during intestinal absorption and renal reuptake.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"51d7b65a-6b74-510e-b56f-2d6b26c6957d","mechanism_event_label":"The gut and kidney transport machinery helps determine phenylalanine availability.","subject":{"id":"10307ad9-80a3-56be-a7f5-740c9362297f","slug":"slc6a19","display_name":"Human neutral amino acid transporter B0AT1 / SLC6A19","entity_type_key":"protein"},"object":{"id":"190407ad-0219-54b5-b05f-7c75f3895ca6","slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"51d7b65a-6b74-510e-b56f-2d6b26c6957d","stable_key":"56f1d914-e7da-595a-af69-c217b2b47407:l-phenylalanine-renal-transporter-event","event_type":"observed_relationship","label":"The gut and kidney transport machinery helps determine phenylalanine availability.","description":"B0AT1/SLC6A19 transports neutral amino acids including phenylalanine during intestinal absorption and renal reuptake.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"10307ad9-80a3-56be-a7f5-740c9362297f","slug":"slc6a19","display_name":"Human neutral amino acid transporter B0AT1 / SLC6A19","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"190407ad-0219-54b5-b05f-7c75f3895ca6","slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human B0AT1 structural and transport study; established physiological role described in abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Transporter identity does not specify a universal saturation threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Phenylalanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The gut and kidney transport machinery helps determine phenylalanine availability.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Structure-guided development of a potent human B0AT1 inhibitor effective in a mouse model of phenylketonuria. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42350764/ · DOI 10.1038/s42003-026-10535-y","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"Recorded as acting during intestinal absorption and renal reuptake, both of which are inward.","entity":null},{"dimension":"transport_pool","value_text":"the enterocyte and tubule cell interior","comparator":null,"unit":null,"notes":"Recorded as acting during intestinal absorption and renal reuptake, both of which are inward.","entity":null}],"evidence":[{"id":"071b3c15-1f17-5005-a7e4-ec79fb0c607d","evidence_kind":"source_excerpt","locator":"Lines 166-172","start_line":166,"end_line":172,"excerpt":"## l-phenylalanine-renal-transporter\nThe gut and kidney transport machinery helps determine phenylalanine availability.\nB0AT1/SLC6A19 transports neutral amino acids including phenylalanine during intestinal absorption and renal reuptake.\nModel: Human B0AT1 structural and transport study; established physiological role described in abstract.\nLimitations: Transporter identity does not specify a universal saturation threshold.\nEvidence access: Primary abstract\nStructure-guided development of a potent human B0AT1 inhibitor effective in a mouse model of phenylketonuria. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42350764/ · DOI 10.1038/s42003-026-10535-y","model_system":"Human B0AT1 structural and transport study; established physiological role described in abstract.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54de7c56-1e60-5d7b-8ef9-852c58ae92ba","stable_key":"import-56f1d914-e7da-595a-af69-c217b2b47407","title":"L-Phenylalanine: transport, protein synthesis, cofactor recycling and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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