{"id":"5e660c96-7d62-59fd-8dfe-0ac8e0eafd88","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-microbiome-context","predicate":"changes_in_trial","statement":"In a 120-person trial across four sweeteners and two controls, stevia was among the interventions associated with distinct microbiome and metabolome changes; significant group-level glycemic impairment was reported for saccharin and sucralose.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1e5a6131-740f-589d-b217-ff19826f9308","mechanism_event_label":"A microbiome change should not be relabeled as demonstrated stevia-induced glucose intolerance.","subject":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"object":{"id":"049c169a-ffc3-5f43-be55-50bea8ac99b3","slug":"human-stevia-two-week-microbiome","display_name":"Human two-week stevia microbiome and metabolome responses","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1e5a6131-740f-589d-b217-ff19826f9308","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-microbiome-context-event","event_type":"observed_relationship","label":"A microbiome change should not be relabeled as demonstrated stevia-induced glucose intolerance.","description":"In a 120-person trial across four sweeteners and two controls, stevia was among the interventions associated with distinct microbiome and metabolome changes; significant group-level glycemic impairment was reported for saccharin and sucralose.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"049c169a-ffc3-5f43-be55-50bea8ac99b3","slug":"human-stevia-two-week-microbiome","display_name":"Human two-week stevia microbiome and metabolome responses","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Two-week randomized human trial with glucose-vehicle and untreated controls.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The 120 participants were spread across arms; the findings do not make all sweeteners interchangeable or establish clinical disease causation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A microbiome change should not be relabeled as demonstrated stevia-induced glucose intolerance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35987213/ · DOI 10.1016/j.cell.2022.07.016","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fd6d4734-023d-5baf-93fe-5657cc5503b7","evidence_kind":"source_excerpt","locator":"Lines 410-416","start_line":410,"end_line":416,"excerpt":"## stevia-microbiome-context\nA microbiome change should not be relabeled as demonstrated stevia-induced glucose intolerance.\nIn a 120-person trial across four sweeteners and two controls, stevia was among the interventions associated with distinct microbiome and metabolome changes; significant group-level glycemic impairment was reported for saccharin and sucralose.\nModel: Two-week randomized human trial with glucose-vehicle and untreated controls.\nLimitations: The 120 participants were spread across arms; the findings do not make all sweeteners interchangeable or establish clinical disease causation.\nEvidence access: Primary abstract\nPersonalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35987213/ · DOI 10.1016/j.cell.2022.07.016","model_system":"Two-week randomized human trial with glucose-vehicle and untreated controls.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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