{"id":"5e4d2857-4590-58d5-995f-4899c61b52fa","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-muscle-does-not-compensate","predicate":"preserves_measured_pool","statement":"Skeletal muscle mass correlated with baseline metabolic heat production but not with non-shivering thermogenesis, and skin blood flow and skin temperatures did not correlate with non-shivering thermogenesis or brown adipose volume.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"adc9f6a0-c9d9-5a3e-8464-f4dd7e36c148","mechanism_event_label":"Muscle does not quietly take over the job; it just starts shivering sooner.","subject":{"id":"80754dff-502f-5b12-8121-50eede4be10a","slug":"skeletal-muscle-tissue","display_name":"Skeletal muscle as a thermogenic and postural organ","entity_type_key":"cell_type"},"object":{"id":"b9c6d7cb-e75b-5be7-ad61-557068101b5f","slug":"non-shivering-thermogenesis","display_name":"Non-shivering thermogenesis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"adc9f6a0-c9d9-5a3e-8464-f4dd7e36c148","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-muscle-does-not-compensate-event","event_type":"observed_intervention","label":"Muscle does not quietly take over the job; it just starts shivering sooner.","description":"Skeletal muscle mass correlated with baseline metabolic heat production but not with non-shivering thermogenesis, and skin blood flow and skin temperatures did not correlate with non-shivering thermogenesis or brown adipose volume.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6bf71b35-989d-5a2e-a483-abbb15e979e4","slug":"skin-blood-flow","display_name":"Skin blood flow","entity_type_key":"cellular_process"},"role":"uncorrelated_measure","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"80754dff-502f-5b12-8121-50eede4be10a","slug":"skeletal-muscle-tissue","display_name":"Skeletal muscle as a thermogenic and postural organ","entity_type_key":"cell_type"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b9c6d7cb-e75b-5be7-ad61-557068101b5f","slug":"non-shivering-thermogenesis","display_name":"Non-shivering thermogenesis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/cold-research/32948898.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"699fc07665c5f8800951348b6948dba539ed6aed5d1d354d4793be8f9f731b6a\", \"start_char\": 0, \"end_char\": 1697, \"text_sha256\": \"699fc07665c5f8800951348b6948dba539ed6aed5d1d354d4793be8f9f731b6a\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Eighteen men with measured brown adipose volume during gradual cold exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Gradual cooling to 18.6 degrees C for non-shivering thermogenesis and 11.6 degrees C for shivering onset","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Correlational human physiology. It tests whether muscle compensates for low brown fat, and finds an earlier shivering onset instead.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Muscle does not quietly take over the job; it just starts shivering sooner.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p32948898] Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans. (2020). https://pubmed.ncbi.nlm.nih.gov/32948898/ DOI: 10.1007/s00421-020-04496-1","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brown adipose tissue and skeletal muscle","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b6fe12da-6c45-5250-ba99-7534c4b64dd3","evidence_kind":"source_excerpt","locator":"Lines 520-531","start_line":520,"end_line":531,"excerpt":"### cold-muscle-does-not-compensate\nSkeletal muscle mass correlated with baseline metabolic heat production but not with non-shivering thermogenesis, and skin blood flow and skin temperatures did not correlate with non-shivering thermogenesis or brown adipose volume.\nCondition category: normal\nnutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.\nplain_language: Muscle does not quietly take over the job; it just starts shivering sooner.\norganism: Human\ntissue_or_cell_type: Brown adipose tissue and skeletal muscle\nexperimental_model: Eighteen men with measured brown adipose volume during gradual cold exposure\nlimitations: Correlational human physiology. It tests whether muscle compensates for low brown fat, and finds an earlier shivering onset instead.\nexposure: Gradual cooling to 18.6 degrees C for non-shivering thermogenesis and 11.6 degrees C for shivering onset\nevidence_span: {\"source_cache\": \"artifacts/cold-research/32948898.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"699fc07665c5f8800951348b6948dba539ed6aed5d1d354d4793be8f9f731b6a\", \"start_char\": 0, \"end_char\": 1697, \"text_sha256\": \"699fc07665c5f8800951348b6948dba539ed6aed5d1d354d4793be8f9f731b6a\"}\n[cold-p32948898] Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans. (2020). https://pubmed.ncbi.nlm.nih.gov/32948898/ DOI: 10.1007/s00421-020-04496-1","model_system":"Eighteen men with measured brown adipose volume during gradual cold exposure","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [cold-p32948898] Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans. (2020). https://pubmed.ncbi.nlm.nih.gov/32948898/ DOI: 10.1007/s00421-020-04496-1","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"feeccadc-1392-573e-a0b5-0939ee5de6e2","stable_key":"import-b3c3f45a-50fb-5b79-98d7-5e5228df00db","title":"Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"557f074d372c49c502c34e648651aff7ebf2c8816305d2d2f08e338a7e96a5f0","revision_id":"ecc19e8d-40db-5b5d-b98e-0507f645976c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}