{"id":"5e3c1d11-014f-5330-83d7-1d52d9236cf0","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-pregnancy-verbal","predicate":"does-not-significantly-improve","statement":"Verbal IQ at 5–6 years averaged 89.5 versus 90.2 with maternal iodine versus placebo; reported difference −0.7 (95% CI −2.9 to 1.5), P=0.77.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"b8540ebc-10c6-549b-aa28-ede0797c2c09","mechanism_event_label":"Starting iodine during this mildly deficient pregnancy trial did not significantly improve verbal IQ.","subject":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"object":{"id":"995df0d3-c968-5e52-a95f-670a5656eed5","slug":"child-wppsi-verbal-iq","display_name":"Child WPPSI-III verbal IQ score","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b8540ebc-10c6-549b-aa28-ede0797c2c09","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-pregnancy-verbal-event","event_type":"observed_intervention","label":"Starting iodine during this mildly deficient pregnancy trial did not significantly improve verbal IQ.","description":"Verbal IQ at 5–6 years averaged 89.5 versus 90.2 with maternal iodine versus placebo; reported difference −0.7 (95% CI −2.9 to 1.5), P=0.77.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"supplemented nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"995df0d3-c968-5e52-a95f-670a5656eed5","slug":"child-wppsi-verbal-iq","display_name":"Child WPPSI-III verbal IQ score","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary full PDF Methods; Table2 and Fig2; Discussion, pp.853–863.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled maternal trial in Bangkok and Bangalore; 832 women randomized, 313 children assessed for IQ and 315 for executive function at age 5–6","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"200 micrograms iodine/day as potassium iodide until delivery; mean enrollment 10.7 weeks gestation; baseline median urinary iodine 131 micrograms/L; IQ iodine 159/placebo 154, executive function 159/156.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mild group-level deficiency with site differences: Thailand deficient and India at low adequacy. Substantial attrition was balanced between groups; measured baseline characteristics were similar in those followed and lost. This does not test preconception treatment or severe deficiency. Reported differences, CIs and mixed-model P values are retained as published.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Starting iodine during this mildly deficient pregnancy trial did not significantly improve verbal IQ.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iod-clin-gow2017] Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial. (2017). https://pubmed.ncbi.nlm.nih.gov/29030199/ DOI: 10.1016/s2213-8587(17)30332-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Maternal iodine status and child neurodevelopment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"176d7126-ee9d-5e76-b3ad-c4e02436f5ed","evidence_kind":"source_excerpt","locator":"Lines 1370-1382","start_line":1370,"end_line":1382,"excerpt":"### iod-clin-pregnancy-verbal\nVerbal IQ at 5–6 years averaged 89.5 versus 90.2 with maternal iodine versus placebo; reported difference −0.7 (95% CI −2.9 to 1.5), P=0.77.\nCondition category: nutrient_deficiency\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Starting iodine during this mildly deficient pregnancy trial did not significantly improve verbal IQ.\norganism: Homo sapiens\ntissue_or_cell_type: Maternal iodine status and child neurodevelopment\nexperimental_model: Randomized double-blind placebo-controlled maternal trial in Bangkok and Bangalore; 832 women randomized, 313 children assessed for IQ and 315 for executive function at age 5–6\nlimitations: Mild group-level deficiency with site differences: Thailand deficient and India at low adequacy. Substantial attrition was balanced between groups; measured baseline characteristics were similar in those followed and lost. This does not test preconception treatment or severe deficiency. Reported differences, CIs and mixed-model P values are retained as published.\nexposure: 200 micrograms iodine/day as potassium iodide until delivery; mean enrollment 10.7 weeks gestation; baseline median urinary iodine 131 micrograms/L; IQ iodine 159/placebo 154, executive function 159/156.\ncross_nutrient: false\nevidence_location: Primary full PDF Methods; Table2 and Fig2; Discussion, pp.853–863.\n[iod-clin-gow2017] Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial. (2017). https://pubmed.ncbi.nlm.nih.gov/29030199/ DOI: 10.1016/s2213-8587(17)30332-7","model_system":"Randomized double-blind placebo-controlled maternal trial in Bangkok and Bangalore; 832 women randomized, 313 children assessed for IQ and 315 for executive function at age 5–6","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iod-clin-gow2017] Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial. 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