{"id":"5e1e6f34-f22e-52fb-86f9-75ce65850c28","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-bdnf-loss","predicate":"loss_blocks","statement":"Lithium failed to protect cortical neurons from Bdnf heterozygous or homozygous knockout mice against glutamate toxicity.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1f26c507-2b48-5144-ba68-5f3b475c18dc","mechanism_event_label":"The protective response required intact survival machinery.","subject":{"id":"8d4e2cbf-5be6-54a1-8b6e-5195fe680373","slug":"mouse-bdnf","display_name":"Mouse brain-derived neurotrophic factor / Bdnf","entity_type_key":"protein"},"object":{"id":"65295305-2871-5909-a1bd-829036e5bb0e","slug":"mouse-cortical-glutamate-survival","display_name":"Mouse cortical-neuron survival during glutamate challenge","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1f26c507-2b48-5144-ba68-5f3b475c18dc","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-bdnf-loss-event","event_type":"observed_relationship","label":"The protective response required intact survival machinery.","description":"Lithium failed to protect cortical neurons from Bdnf heterozygous or homozygous knockout mice against glutamate toxicity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8d4e2cbf-5be6-54a1-8b6e-5195fe680373","slug":"mouse-bdnf","display_name":"Mouse brain-derived neurotrophic factor / Bdnf","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"65295305-2871-5909-a1bd-829036e5bb0e","slug":"mouse-cortical-glutamate-survival","display_name":"Mouse cortical-neuron survival during glutamate challenge","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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