{"id":"5e010707-66ba-58ef-af84-84cb9f58066c","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-crc-il8","predicate":"reduces","statement":"In 37 colorectal-cancer patients receiving chemotherapy, 100 mg/day fisetin for seven weeks lowered plasma IL-8 relative to placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"1fc2b33a-fba3-5c92-aee1-0911b43d8a76","mechanism_event_label":"A small trial measured an inflammatory marker response.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"5dd031e8-9ede-5db7-a4e1-961de31f0b49","slug":"cxcl8","display_name":"Human interleukin-8 / CXCL8","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"1fc2b33a-fba3-5c92-aee1-0911b43d8a76","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-crc-il8-event","event_type":"observed_relationship","label":"A small trial measured an inflammatory marker response.","description":"In 37 colorectal-cancer patients receiving chemotherapy, 100 mg/day fisetin for seven weeks lowered plasma IL-8 relative to placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5dd031e8-9ede-5db7-a4e1-961de31f0b49","slug":"cxcl8","display_name":"Human interleukin-8 / CXCL8","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind trial; 18 fisetin and 19 placebo.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No tumor-response or survival benefit demonstrated; plasma concentration is not direct cytokine binding.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A small trial measured an inflammatory marker response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29541713/ · DOI 10.1039/c7fo01898c","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"7a43d5c9-12c1-5804-bed9-8f10915450ed","evidence_kind":"source_excerpt","locator":"Lines 504-510","start_line":504,"end_line":510,"excerpt":"## fisetin-crc-il8\nA small trial measured an inflammatory marker response.\nIn 37 colorectal-cancer patients receiving chemotherapy, 100 mg/day fisetin for seven weeks lowered plasma IL-8 relative to placebo.\nModel: Randomized double-blind trial; 18 fisetin and 19 placebo.\nLimitations: No tumor-response or survival benefit demonstrated; plasma concentration is not direct cytokine binding.\nEvidence access: Primary abstract\nEffect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29541713/ · DOI 10.1039/c7fo01898c","model_system":"Randomized double-blind trial; 18 fisetin and 19 placebo.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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