{"id":"5de81f98-70ee-5016-8647-cbc0315a3604","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-iron-meal","predicate":"did_not_inhibit_in_meal","statement":"When the corresponding iron-to-zinc ratios were administered with a meal, zinc absorption was 25%, 23% and 22%, without the inhibitory iron effect detected in fasting water. Two weeks of iron preloading also did not alter zinc absorption from water.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"d852e1f0-4a0d-58c3-b7ed-65f963be813d","mechanism_event_label":"The fasting-solution result did not carry over to the tested meal.","subject":{"id":"59d6d1cd-df32-5b58-b950-3188bc7b95d6","slug":"iron-ii","display_name":"Ferrous iron","entity_type_key":"ion"},"object":{"id":"957321e4-a5db-5a5d-851b-72069bab3efd","slug":"intestinal-zinc-absorption","display_name":"Intestinal zinc absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d852e1f0-4a0d-58c3-b7ed-65f963be813d","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-iron-meal-event","event_type":"observed_intervention","label":"The fasting-solution result did not carry over to the tested meal.","description":"When the corresponding iron-to-zinc ratios were administered with a meal, zinc absorption was 25%, 23% and 22%, without the inhibitory iron effect detected in fasting water. Two weeks of iron preloading also did not alter zinc absorption from water.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"absorbed_nutrient_ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"dietary_context","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"59d6d1cd-df32-5b58-b950-3188bc7b95d6","slug":"iron-ii","display_name":"Ferrous iron","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"957321e4-a5db-5a5d-851b-72069bab3efd","slug":"intestinal-zinc-absorption","display_name":"Intestinal zinc absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Zinc(II) ion (absorbed_nutrient_ion); Iron (dietary_context)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Indexed primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-clinical-sources/sandstrom1985.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"aa462f6a961ec4190690f8def1be1f5e54491574698b131992161a989103ca76\", \"utf8_bytes\": 1044}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human 65Zn tracer study with whole-body counting after two weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Ferrous iron with ascorbic acid; Fe:Zn molar ratios 1:1, 2.5:1 and 25:1, in fasting water or a meal; histidine and iron-preloading comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Meal matrix, iron ratio and ligand differed. Absolute administered amounts and sample sizes were not verified in the indexed abstract; no universal spacing rule follows.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The fasting-solution result did not carry over to the tested meal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-clin-sandstrom1985] Oral iron, dietary ligands and zinc absorption. (1985). https://pubmed.ncbi.nlm.nih.gov/3973750/ DOI: 10.1093/jn/115.3.411","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal absorption","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4971bd6f-e521-5483-9e96-f8cd32f10457","evidence_kind":"source_excerpt","locator":"Lines 1241-1254","start_line":1241,"end_line":1254,"excerpt":"### zn-clin-iron-meal\nWhen the corresponding iron-to-zinc ratios were administered with a meal, zinc absorption was 25%, 23% and 22%, without the inhibitory iron effect detected in fasting water. Two weeks of iron preloading also did not alter zinc absorption from water.\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The fasting-solution result did not carry over to the tested meal.\norganism: Homo sapiens\ntissue_or_cell_type: Intestinal absorption\nexperimental_model: Human 65Zn tracer study with whole-body counting after two weeks\nlimitations: Meal matrix, iron ratio and ligand differed. Absolute administered amounts and sample sizes were not verified in the indexed abstract; no universal spacing rule follows.\nexposure: Ferrous iron with ascorbic acid; Fe:Zn molar ratios 1:1, 2.5:1 and 25:1, in fasting water or a meal; histidine and iron-preloading comparisons.\ncross_nutrient: Zinc(II) ion (absorbed_nutrient_ion); Iron (dietary_context)\nevidence_location: Indexed primary abstract.\nevidence_span: {\"source_cache\": \"artifacts/zinc-clinical-sources/sandstrom1985.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"aa462f6a961ec4190690f8def1be1f5e54491574698b131992161a989103ca76\", \"utf8_bytes\": 1044}\n[zn-clin-sandstrom1985] Oral iron, dietary ligands and zinc absorption. (1985). https://pubmed.ncbi.nlm.nih.gov/3973750/ DOI: 10.1093/jn/115.3.411","model_system":"Human 65Zn tracer study with whole-body counting after two weeks","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-clin-sandstrom1985] Oral iron, dietary ligands and zinc absorption. (1985). https://pubmed.ncbi.nlm.nih.gov/3973750/ DOI: 10.1093/jn/115.3.411","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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