{"id":"5de2b054-08d1-58ef-a854-5b950832cebb","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-adk-product-removal","predicate":"supports","statement":"ADK variants impaired recombinant enzyme activity and were linked to increased adenosine excretion and SAM/SAH/methionine accumulation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0bf60fdd-4b0d-5c29-9678-0e376aee50b9","mechanism_event_label":"Removing one reaction product helps keep the recycling pathway moving.","subject":{"id":"cd4fc54d-1163-58f6-b235-e05151190f99","slug":"adk","display_name":"Human adenosine kinase / ADK","entity_type_key":"protein"},"object":{"id":"674a5071-dbf3-57d0-90d3-1a4d4a9772c2","slug":"human-adenosine-methionine-cycle-coupling","display_name":"Adenosine removal coupled to the human methionine cycle","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0bf60fdd-4b0d-5c29-9678-0e376aee50b9","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-adk-product-removal-event","event_type":"observed_relationship","label":"Removing one reaction product helps keep the recycling pathway moving.","description":"ADK variants impaired recombinant enzyme activity and were linked to increased adenosine excretion and SAM/SAH/methionine accumulation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"cd4fc54d-1163-58f6-b235-e05151190f99","slug":"adk","display_name":"Human adenosine kinase / ADK","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"674a5071-dbf3-57d0-90d3-1a4d4a9772c2","slug":"human-adenosine-methionine-cycle-coupling","display_name":"Adenosine removal coupled to the human methionine cycle","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b1001072-f1ab-54a1-80fd-d15a41e31adb","slug":"adenosine","display_name":"Adenosine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"825f2da2-01bc-5874-a3c6-64f5ac867db5","slug":"s-adenosylmethionine","display_name":"S-Adenosyl-L-methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"e84829b1-0607-558e-8add-aaa3af4747e7","slug":"s-adenosylhomocysteine","display_name":"S-Adenosyl-L-homocysteine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""},{"entity":{"id":"1a5e2abf-e98c-5ee2-8197-4434fcc1e88a","slug":"ahcy","display_name":"Human adenosylhomocysteinase / AHCY","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":6,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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