{"id":"5d9fa6d0-0c8c-5b86-9acf-942d1f5ef67a","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-red-cell-compartment","predicate":"does_not_change_tested","statement":"Erythrocyte glutamate and aspartate concentrations did not change in either arm of the eight-person MSG/carbohydrate experiment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"ccaabeb3-3d3f-5093-90dc-167c688a9b30","mechanism_event_label":"A plasma change did not imply the same change in red cells.","subject":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"object":{"id":"28fe4759-0e24-567a-933a-19ffaa7b4784","slug":"human-msg-erythrocyte-glutamate-aspartate","display_name":"Human erythrocyte glutamate/aspartate during MSG loading","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ccaabeb3-3d3f-5093-90dc-167c688a9b30","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-red-cell-compartment-event","event_type":"observed_relationship","label":"A plasma change did not imply the same change in red cells.","description":"Erythrocyte glutamate and aspartate concentrations did not change in either arm of the eight-person MSG/carbohydrate experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"28fe4759-0e24-567a-933a-19ffaa7b4784","slug":"human-msg-erythrocyte-glutamate-aspartate","display_name":"Human erythrocyte glutamate/aspartate during MSG loading","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"150 mg/kg MSG with or without hydrolyzed corn starch.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Other cells and later times were not established by this result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A plasma change did not imply the same change in red cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of carbohydrate on plasma and erythrocyte glutamate levels in humans ingesting large doses of monosodium L-glutamate in water. · 1983 · https://pubmed.ncbi.nlm.nih.gov/6133445/ · DOI 10.1093/ajcn/37.6.961","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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