{"id":"5d86c338-f4c7-5be7-bfce-40db2c36418d","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-acute-shear-stress","predicate":"reduces","statement":"Forearm vascular conductance was reduced at 15 minutes of immersion and 30 minutes after, and total and antegrade shear stress and the oscillatory shear index were reduced 30 minutes after immersion, with no difference in retrograde shear.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"dc64028c-a605-5d8f-ad52-2c6101ab0a48","mechanism_event_label":"The vessels in the arm stayed narrowed for at least half an hour afterwards.","subject":{"id":"96a7dff2-caf4-51c1-93c4-c9ed08c05c9a","slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"},"object":{"id":"3bf4c498-b75c-5192-995f-44c85faf28fe","slug":"forearm-vascular-conductance","display_name":"Forearm vascular conductance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"dc64028c-a605-5d8f-ad52-2c6101ab0a48","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-acute-shear-stress-event","event_type":"observed_intervention","label":"The vessels in the arm stayed narrowed for at least half an hour afterwards.","description":"Forearm vascular conductance was reduced at 15 minutes of immersion and 30 minutes after, and total and antegrade shear stress and the oscillatory shear index were reduced 30 minutes after immersion, with no difference in retrograde shear.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6a06a5db-17f6-5f7b-aeeb-3eed8f8be8c1","slug":"arterial-shear-stress","display_name":"Brachial artery antegrade and total shear stress","entity_type_key":"cellular_process"},"role":"measured_property","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"96a7dff2-caf4-51c1-93c4-c9ed08c05c9a","slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"3bf4c498-b75c-5192-995f-44c85faf28fe","slug":"forearm-vascular-conductance","display_name":"Forearm vascular conductance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/cold-research/37866096.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2180ef37d9e3dda6b7785769dcc2e4deb89b07a12ffed469e52c80af563cff54\", \"start_char\": 0, \"end_char\": 1665, \"text_sha256\": \"2180ef37d9e3dda6b7785769dcc2e4deb89b07a12ffed469e52c80af563cff54\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Sixteen healthy adults completing one 15-minute immersion at 10 degrees C with Doppler ultrasound and blood sampling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"One 15-minute immersion at 10 degrees C","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A small single-bout study. Beta-endorphin did not change, which bears on the common attribution of the mood effect to endorphins.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The vessels in the arm stayed narrowed for at least half an hour afterwards.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p37866096] Cardiovascular and mood responses to an acute bout of cold water immersion. (2023). https://pubmed.ncbi.nlm.nih.gov/37866096/ DOI: 10.1016/j.jtherbio.2023.103727","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brachial artery and mood","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cec8b9b3-7cd7-55a8-a408-fbf1e3fba5a3","evidence_kind":"source_excerpt","locator":"Lines 754-765","start_line":754,"end_line":765,"excerpt":"### cold-acute-shear-stress\nForearm vascular conductance was reduced at 15 minutes of immersion and 30 minutes after, and total and antegrade shear stress and the oscillatory shear index were reduced 30 minutes after immersion, with no difference in retrograde shear.\nCondition category: normal\nnutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.\nplain_language: The vessels in the arm stayed narrowed for at least half an hour afterwards.\norganism: Human\ntissue_or_cell_type: Brachial artery and mood\nexperimental_model: Sixteen healthy adults completing one 15-minute immersion at 10 degrees C with Doppler ultrasound and blood sampling\nlimitations: A small single-bout study. Beta-endorphin did not change, which bears on the common attribution of the mood effect to endorphins.\nexposure: One 15-minute immersion at 10 degrees C\nevidence_span: {\"source_cache\": \"artifacts/cold-research/37866096.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2180ef37d9e3dda6b7785769dcc2e4deb89b07a12ffed469e52c80af563cff54\", \"start_char\": 0, \"end_char\": 1665, \"text_sha256\": \"2180ef37d9e3dda6b7785769dcc2e4deb89b07a12ffed469e52c80af563cff54\"}\n[cold-p37866096] Cardiovascular and mood responses to an acute bout of cold water immersion. (2023). https://pubmed.ncbi.nlm.nih.gov/37866096/ DOI: 10.1016/j.jtherbio.2023.103727","model_system":"Sixteen healthy adults completing one 15-minute immersion at 10 degrees C with Doppler ultrasound and blood sampling","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [cold-p37866096] Cardiovascular and mood responses to an acute bout of cold water immersion. 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