{"id":"5d7f11a3-32ae-51be-945a-79fbdb7d983e","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-regional-autoimmunity","predicate":"higher-regional-exposure-associated-with","statement":"Five-year autoimmune thyroiditis incidence was 0.2%, 1.0% and 1.3% across the three increasing regional iodine-exposure categories.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0ed71d0e-afeb-5847-abd4-9e052877ae89","mechanism_event_label":"The same cohort also found more autoimmune thyroiditis in the higher-exposure regions.","subject":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"object":{"id":"b122c305-20d7-5a1f-ba71-d7c8cf71e849","slug":"autoimmune-thyroiditis-incidence","display_name":"Autoimmune thyroiditis incidence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0ed71d0e-afeb-5847-abd4-9e052877ae89","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-regional-autoimmunity-event","event_type":"observed_intervention","label":"The same cohort also found more autoimmune thyroiditis in the higher-exposure regions.","description":"Five-year autoimmune thyroiditis incidence was 0.2%, 1.0% and 1.3% across the three increasing regional iodine-exposure categories.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"240520a5-5777-5f4f-aa45-1dfca6abc55d","slug":"urinary-iodine-concentration","display_name":"Urinary iodine concentration","entity_type_key":"cellular_process"},"role":"regional exposure proxy","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b122c305-20d7-5a1f-ba71-d7c8cf71e849","slug":"autoimmune-thyroiditis-incidence","display_name":"Autoimmune thyroiditis incidence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Prospective five-year observational follow-up in three Chinese regions;3761 enrolled and 3018 followed","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Regional baseline median urinary iodine 84, 243 and 651 micrograms/L; followed 1999–2004.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Regional exposure is not randomized individual dosing; confounding and baseline susceptibility may contribute. Median urinary iodine defines cohort exposure, not an individual disease threshold. Association does not establish the immune mechanism or show that every person with antibodies responds identically to iodine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The same cohort also found more autoimmune thyroiditis in the higher-exposure regions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iod-clin-teng2006] Effect of iodine intake on thyroid diseases in China. (2006). https://pubmed.ncbi.nlm.nih.gov/16807415/ DOI: 10.1056/nejmoa054022","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum thyroid function/antibodies and thyroid ultrasound","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2375b28e-e873-53a2-9f28-316642c5bee4","evidence_kind":"source_excerpt","locator":"Lines 1496-1508","start_line":1496,"end_line":1508,"excerpt":"### iod-clin-regional-autoimmunity\nFive-year autoimmune thyroiditis incidence was 0.2%, 1.0% and 1.3% across the three increasing regional iodine-exposure categories.\nCondition category: normal\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The same cohort also found more autoimmune thyroiditis in the higher-exposure regions.\norganism: Homo sapiens\ntissue_or_cell_type: Serum thyroid function/antibodies and thyroid ultrasound\nexperimental_model: Prospective five-year observational follow-up in three Chinese regions;3761 enrolled and 3018 followed\nlimitations: Regional exposure is not randomized individual dosing; confounding and baseline susceptibility may contribute. Median urinary iodine defines cohort exposure, not an individual disease threshold. Association does not establish the immune mechanism or show that every person with antibodies responds identically to iodine.\nexposure: Regional baseline median urinary iodine 84, 243 and 651 micrograms/L; followed 1999–2004.\ncross_nutrient: false\nevidence_location: Primary indexed abstract.\n[iod-clin-teng2006] Effect of iodine intake on thyroid diseases in China. (2006). https://pubmed.ncbi.nlm.nih.gov/16807415/ DOI: 10.1056/nejmoa054022","model_system":"Prospective five-year observational follow-up in three Chinese regions;3761 enrolled and 3018 followed","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iod-clin-teng2006] Effect of iodine intake on thyroid diseases in China. (2006). https://pubmed.ncbi.nlm.nih.gov/16807415/ DOI: 10.1056/nejmoa054022","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"76da623d-a34a-5a5c-a942-d7571a85c486","stable_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a4885eb6f58bad4a4514c958b63834619e57b10aa7f694aa97d0f65c7d36548f","revision_id":"ea8001a1-b576-5eda-a193-883c7ad59b73","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}