{"id":"5d6371dc-a95b-5625-aba4-ce318cea3c5d","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-isomer-comparison","predicate":"had_similar_dose_normalized_exposure_to","statement":"Dose-normalized peak concentrations and areas under the curve did not significantly differ between isomers.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"364a8259-2cec-5357-9832-ae94535bebb2","mechanism_event_label":"Neither isomer showed a clear advantage in this comparison.","subject":{"id":"de045f76-8ea2-5f04-84a6-595e2d598107","slug":"cis-nasunin","display_name":"cis-Nasunin","entity_type_key":"small_molecule"},"object":{"id":"6c0572c8-5407-5192-b802-7f8c8be12293","slug":"trans-nasunin","display_name":"trans-Nasunin","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"364a8259-2cec-5357-9832-ae94535bebb2","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-isomer-comparison-event","event_type":"observed_intervention","label":"Neither isomer showed a clear advantage in this comparison.","description":"Dose-normalized peak concentrations and areas under the curve did not significantly differ between isomers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"de045f76-8ea2-5f04-84a6-595e2d598107","slug":"cis-nasunin","display_name":"cis-Nasunin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6c0572c8-5407-5192-b802-7f8c8be12293","slug":"trans-nasunin","display_name":"trans-Nasunin","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/nasunin-research/16848510.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a\", \"start_char\": 0, \"end_char\": 1308, \"text_sha256\": \"72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Oral isomer pharmacokinetics with chromatographic metabolite analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Oral purified cis/trans nasunin; plasma follow-up to 8 h","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Dose-normalized Cmax/AUC comparison is not absolute oral bioavailability. Nondetection applies to the tested analytes, method and window; no human or blood-brain-barrier conclusion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Nasunin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Neither isomer showed a clear advantage in this comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[nasunin-p16848510] Gastrointestinal uptake of nasunin, acylated anthocyanin in eggplant. (2006). https://pubmed.ncbi.nlm.nih.gov/16848510/ DOI: 10.1021/jf060238s","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma and urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"21923b37-87d7-5d0d-bbbe-d908eeda1a9b","evidence_kind":"source_excerpt","locator":"Lines 744-755","start_line":744,"end_line":755,"excerpt":"### nasunin-isomer-comparison\nDose-normalized peak concentrations and areas under the curve did not significantly differ between isomers.\nCondition category: normal\nnutrient_topic: Nasunin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Neither isomer showed a clear advantage in this comparison.\norganism: Rats\ntissue_or_cell_type: Plasma and urine\nexperimental_model: Oral isomer pharmacokinetics with chromatographic metabolite analysis\nlimitations: Dose-normalized Cmax/AUC comparison is not absolute oral bioavailability. Nondetection applies to the tested analytes, method and window; no human or blood-brain-barrier conclusion.\nexposure: Oral purified cis/trans nasunin; plasma follow-up to 8 h\nevidence_span: {\"source_cache\": \"artifacts/nasunin-research/16848510.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a\", \"start_char\": 0, \"end_char\": 1308, \"text_sha256\": \"72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a\"}\n[nasunin-p16848510] Gastrointestinal uptake of nasunin, acylated anthocyanin in eggplant. (2006). https://pubmed.ncbi.nlm.nih.gov/16848510/ DOI: 10.1021/jf060238s","model_system":"Oral isomer pharmacokinetics with chromatographic metabolite analysis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [nasunin-p16848510] Gastrointestinal uptake of nasunin, acylated anthocyanin in eggplant. (2006). https://pubmed.ncbi.nlm.nih.gov/16848510/ DOI: 10.1021/jf060238s","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2c43df19-ccb0-58f1-b9a4-bc92cda6de5a","stable_key":"import-e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff","title":"Nasunin: identity, redox chemistry and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"56552c208433294bf9a6c95513d981dbe4d00fd8336c121816d7b8bd6604d50e","revision_id":"b0296d49-32d7-52dc-a23c-5e862da0fba3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}