{"id":"5d4c27fc-ff56-59bf-bae2-6a8a45de5ad9","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-beta-blocker-latency","predicate":"reduces","statement":"Latency to stage 2 sleep decreased by about 14 minutes compared with placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"076ec8b9-e4f7-5577-af6c-0e45ab164a15","mechanism_event_label":"The study measured a specific polysomnographic endpoint.","subject":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"object":{"id":"36b9edba-2a63-5172-ab86-5c4e2b7ab081","slug":"sleep-latency","display_name":"Sleep latency, measurement specified by study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"076ec8b9-e4f7-5577-af6c-0e45ab164a15","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-beta-blocker-latency-event","event_type":"observed_intervention","label":"The study measured a specific polysomnographic endpoint.","description":"Latency to stage 2 sleep decreased by about 14 minutes compared with placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"36b9edba-2a63-5172-ab86-5c4e2b7ab081","slug":"sleep-latency","display_name":"Sleep latency, measurement specified by study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/melatonin-research/23024438.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0f886545db45f7067ce68991935dcc3715082dbe31898c939eb64b015d3581f3\", \"start_char\": 0, \"end_char\": 2402, \"text_sha256\": \"0f886545db45f7067ce68991935dcc3715082dbe31898c939eb64b015d3581f3\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"2.5 mg melatonin nightly for three weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small selected group; does not prove every beta-blocker user is deficient or that all low-melatonin states respond identically.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Melatonin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Hypertensive patients taking atenolol or metoprolol; 15 analyzed","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The study measured a specific polysomnographic endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[melatonin-p23024438] Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. 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