{"id":"5ce15af9-6c00-55da-89c0-ed263bd76d9c","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-liver-nash-marker","predicate":"associated_with_lower","statement":"Hepatic DOHH mRNA was lower in sampled patients with NASH.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"42d1e38f-9b2f-5ce2-8c95-230d68ff14c5","mechanism_event_label":"Human tissue provides an association to test.","subject":{"id":"81e7658f-c0f8-505d-9f00-a56f13117982","slug":"human-nash-liver-context","display_name":"Human NASH liver sampling context","entity_type_key":"cellular_process"},"object":{"id":"185dae5b-798b-5fd2-b28d-57b640045a0f","slug":"dohh","display_name":"DOHH","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"42d1e38f-9b2f-5ce2-8c95-230d68ff14c5","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-liver-nash-marker-event","event_type":"observed_relationship","label":"Human tissue provides an association to test.","description":"Hepatic DOHH mRNA was lower in sampled patients with NASH.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"81e7658f-c0f8-505d-9f00-a56f13117982","slug":"human-nash-liver-context","display_name":"Human NASH liver sampling context","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"185dae5b-798b-5fd2-b28d-57b640045a0f","slug":"dohh","display_name":"DOHH","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human liver expression comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Association is not enzyme-activity measurement or proof that spermidine treats NASH.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Human tissue provides an association to test.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36057633/ · DOI 10.1038/s41467-022-32788-x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"48f3b340-3a72-5efd-bce7-7b63a60dd910","evidence_kind":"source_excerpt","locator":"Lines 318-324","start_line":318,"end_line":324,"excerpt":"## spermidine-liver-nash-marker\nHuman tissue provides an association to test.\nHepatic DOHH mRNA was lower in sampled patients with NASH.\nModel: Human liver expression comparison.\nLimitations: Association is not enzyme-activity measurement or proof that spermidine treats NASH.\nEvidence access: Primary full text\nSpermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36057633/ · DOI 10.1038/s41467-022-32788-x","model_system":"Human liver expression comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4348f3f8-0180-58a3-b61c-55d03bb322d2","stable_key":"import-88eb7407-f147-558b-889b-0c89c4e0aa4a","title":"Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"8eec8784bc2bd0384cfd53c6603c4ced8e53c227d9ab29ed85594c43e34c68ef","revision_id":"7c421a18-4526-59f6-b84e-4be533bc35ac","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}