{"id":"5ccb8aee-45ae-5e36-90d7-c7f16f806255","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-lipase-deacylation","predicate":"converts","statement":"Lipase treatment removed the fatty-acid side chain of hericenone C to form deacylhericenone.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"4f2facde-5f29-57a5-bcd1-6ae240670eaa","mechanism_event_label":"Lipase treatment removed the fatty-acid side chain of hericenone C to form deacylhericenone.","subject":{"id":"37495e26-9a9b-56fd-9404-be5edb248275","slug":"lipase","display_name":"Lipase enzyme preparation","entity_type_key":"protein_family"},"object":{"id":"631eaf08-b37b-54d0-910c-7ab40cae5b96","slug":"hericenone-c","display_name":"Hericenone C","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"4f2facde-5f29-57a5-bcd1-6ae240670eaa","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-lipase-deacylation-event","event_type":"observed_relationship","label":"Lipase treatment removed the fatty-acid side chain of hericenone C to form deacylhericenone.","description":"Lipase treatment removed the fatty-acid side chain of hericenone C to form deacylhericenone.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"37495e26-9a9b-56fd-9404-be5edb248275","slug":"lipase","display_name":"Lipase enzyme preparation","entity_type_key":"protein_family"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"631eaf08-b37b-54d0-910c-7ab40cae5b96","slug":"hericenone-c","display_name":"Hericenone C","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9dadb141-158f-5871-9118-4243be47da1c","slug":"deacylhericenone","display_name":"Deacylhericenone","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Hericenone C with lipase","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Incubation interval specified in the primary article","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free digestion followed by structural analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The preparation models possible metabolism but does not establish the responsible human digestive enzyme or in-vivo conversion fraction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hericenones & Erinacines chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hericenones-erinacines","display_name":"Hericenones and erinacines","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Cell-free digestion followed by structural analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Lipase treatment removed the fatty-acid side chain of hericenone C to form deacylhericenone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Deacylated Derivative of Hericenone C Treated by Lipase Shows Enhanced Neuroprotective Properties Compared to Its Parent Compound. (2023). https://pubmed.ncbi.nlm.nih.gov/37299024/ DOI: 10.3390/molecules28114549","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro enzymatic treatment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Hericenone C deacylation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b026f474-22cb-5a28-920d-9410ac2c3d6a","evidence_kind":"source_excerpt","locator":"Lines 66-75","start_line":66,"end_line":75,"excerpt":"## hericenones-erinacines-lipase-deacylation\nLipase treatment removed the fatty-acid side chain of hericenone C to form deacylhericenone.\nModel/species: Cell-free digestion followed by structural analysis\nTissue/system: Hericenone C deacylation\nExposure: Hericenone C with lipase\nRoute: In vitro enzymatic treatment\nDuration: Incubation interval specified in the primary article\nLimits: The preparation models possible metabolism but does not establish the responsible human digestive enzyme or in-vivo conversion fraction.\nPrimary reference: Deacylated Derivative of Hericenone C Treated by Lipase Shows Enhanced Neuroprotective Properties Compared to Its Parent Compound. (2023). https://pubmed.ncbi.nlm.nih.gov/37299024/ DOI: 10.3390/molecules28114549\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Cell-free digestion followed by structural analysis","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"aa7c09fd-ab4a-51ff-b463-d35547dc41ba","stable_key":"import-d39c4b36-9a88-5f52-8e6b-93a248dc4bfc","title":"Hericenones & Erinacines: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"f1ff2966f222f5c463e8e509ec1b1642a0053cd38f121f3847cdd21855c46e85","revision_id":"d00076e0-da87-5100-92ed-0525190b25a1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}