{"id":"5c9c5e72-bf23-57e4-a3aa-8a167508a248","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-different-repletion","predicate":"repletion_differentially_restores","statement":"Prothrombin carboxylation normalized at 200 micrograms/day, whereas other vitamin K markers had not all returned to baseline after short repletion up to 450 micrograms/day.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ab419004-e5cd-56b2-b4ef-036d87c2efc1","mechanism_event_label":"A liver-related marker can recover before an extrahepatic marker.","subject":{"id":"5f9fd13b-5428-5024-a855-9db526855890","slug":"phylloquinone","display_name":"Phylloquinone","entity_type_key":"small_molecule"},"object":{"id":"de0220e7-19ea-5b7e-8521-57abbfe8e945","slug":"vitamin-k-dependent-carboxylation","display_name":"Vitamin K-dependent protein gamma-carboxylation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ab419004-e5cd-56b2-b4ef-036d87c2efc1","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-different-repletion-event","event_type":"biochemical_relationship","label":"A liver-related marker can recover before an extrahepatic marker.","description":"Prothrombin carboxylation normalized at 200 micrograms/day, whereas other vitamin K markers had not all returned to baseline after short repletion up to 450 micrograms/day.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7831d47f-191c-5515-8202-534bc962e1ad","slug":"f2","display_name":"Prothrombin / coagulation factor II / F2","entity_type_key":"protein"},"role":"earlier_restored_marker","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b043ce5c-8537-5099-8421-b07ec993dbde","slug":"bglap","display_name":"Osteocalcin / BGLAP","entity_type_key":"protein"},"role":"other_marker","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5f9fd13b-5428-5024-a855-9db526855890","slug":"phylloquinone","display_name":"Phylloquinone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"de0220e7-19ea-5b7e-8521-57abbfe8e945","slug":"vitamin-k-dependent-carboxylation","display_name":"Vitamin K-dependent protein gamma-carboxylation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/k2-research/12888638.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c57beda0b2c7bdc471fd6f4bfa926e9f12846f040c95689648f599d6cceae874\", \"start_char\": 0, \"end_char\": 1461, \"text_sha256\": \"c57beda0b2c7bdc471fd6f4bfa926e9f12846f040c95689648f599d6cceae874\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Metabolic-unit dietary depletion/repletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"K1 restricted to 18 micrograms/day for 28 days, then stepped repletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"K1 restriction probes shared vitamin K status, not an isolated dietary K2 requirement. Biochemical undercarboxylation is not equivalent to clinical bleeding or fractures.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"k2","display_name":"Vitamin K2 / menaquinone family","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"21 women aged 60–80 years","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A liver-related marker can recover before an extrahepatic marker.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k2-p12888638] Dietary phylloquinone depletion and repletion in older women. (2003). https://pubmed.ncbi.nlm.nih.gov/12888638/ DOI: 10.1093/jn/133.8.2565","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Hepatic and extrahepatic protein markers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"0b9a15dd-2165-57dd-9019-f6a18e94128e","evidence_kind":"source_excerpt","locator":"Lines 1020-1031","start_line":1020,"end_line":1031,"excerpt":"### k2-different-repletion\nProthrombin carboxylation normalized at 200 micrograms/day, whereas other vitamin K markers had not all returned to baseline after short repletion up to 450 micrograms/day.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A liver-related marker can recover before an extrahepatic marker.\norganism: 21 women aged 60–80 years\ntissue_or_cell_type: Hepatic and extrahepatic protein markers\nexperimental_model: Metabolic-unit dietary depletion/repletion\nlimitations: K1 restriction probes shared vitamin K status, not an isolated dietary K2 requirement. Biochemical undercarboxylation is not equivalent to clinical bleeding or fractures.\nexposure: K1 restricted to 18 micrograms/day for 28 days, then stepped repletion\nevidence_span: {\"source_cache\": \"artifacts/k2-research/12888638.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c57beda0b2c7bdc471fd6f4bfa926e9f12846f040c95689648f599d6cceae874\", \"start_char\": 0, \"end_char\": 1461, \"text_sha256\": \"c57beda0b2c7bdc471fd6f4bfa926e9f12846f040c95689648f599d6cceae874\"}\n[k2-p12888638] Dietary phylloquinone depletion and repletion in older women. (2003). https://pubmed.ncbi.nlm.nih.gov/12888638/ DOI: 10.1093/jn/133.8.2565","model_system":"Metabolic-unit dietary depletion/repletion","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [k2-p12888638] Dietary phylloquinone depletion and repletion in older women. (2003). https://pubmed.ncbi.nlm.nih.gov/12888638/ DOI: 10.1093/jn/133.8.2565","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dfeae572-af3d-5042-a10e-e67596f9ab28","stable_key":"import-4fef8d72-f107-5eb5-b2fb-483ca85465e0","title":"Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"dc31aff21110d09b025c177e03b4c5ca8349d52bf5f962285fdbfcf660c0e4f6","revision_id":"850887db-34f6-55aa-9d3e-b8fd3a4a5de3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}