{"id":"5c968f80-1467-5629-93ce-8150cb49fa68","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-sig-rxra-rar-transactivation","predicate":"enhances","statement":"RXRA enhanced RAR-mediated transcription at RA concentrations insufficient to substantially activate RXRA itself.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"1c357d1a-b61a-5330-ab45-31a839350275","mechanism_event_label":"RXRA can assist RAR signaling without equivalent activation of both partners.","subject":{"id":"7dc1ce11-f208-5187-95d9-96b07927df6a","slug":"rxra","display_name":"Retinoid X receptor alpha","entity_type_key":"protein"},"object":{"id":"6c127d6b-61f1-5b4e-a608-3d1aa94296de","slug":"ra-responsive-transcription","display_name":"Retinoic-acid-responsive transcription","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1c357d1a-b61a-5330-ab45-31a839350275","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-sig-rxra-rar-transactivation-event","event_type":"biochemical_relationship","label":"RXRA can assist RAR signaling without equivalent activation of both partners.","description":"RXRA enhanced RAR-mediated transcription at RA concentrations insufficient to substantially activate RXRA itself.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"nutrient-context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"231bc87f-843e-57b3-ad84-06f63f656383","slug":"rara","display_name":"Retinoic acid receptor alpha","entity_type_key":"protein"},"role":"receptor-partner","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"05487b29-8c59-5af8-83cf-cf9c79c5ecb8","slug":"all-trans-retinoic-acid","display_name":"All-trans-retinoic acid","entity_type_key":"small_molecule"},"role":"ligand","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7dc1ce11-f208-5187-95d9-96b07927df6a","slug":"rxra","display_name":"Retinoid X receptor alpha","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"6c127d6b-61f1-5b4e-a608-3d1aa94296de","slug":"ra-responsive-transcription","display_name":"Retinoic-acid-responsive transcription","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_locator","value_text":"Abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Receptor interaction, DNA binding and transfection experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Receptor cotransfection and RA","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reporter-system dependence; 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topical membership is not evidence of a direct dietary effect.\nplain_language: RXRA can assist RAR signaling without equivalent activation of both partners.\norganism: Engineered cellular receptor system\ntissue_or_cell_type: Transfection reporters\nexperimental_model: Receptor interaction, DNA binding and transfection experiments.\nlimitations: Reporter-system dependence; no nutrient dose response.\nevidence_locator: Abstract\nexposure: Receptor cotransfection and RA\n[va-zhang-1992] Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors (1992). https://pubmed.ncbi.nlm.nih.gov/1310350/ DOI: 10.1038/355441a0","model_system":"Receptor interaction, DNA binding and transfection experiments.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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