{"id":"5c45cd02-c79f-5afa-8357-aeecbbddf030","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-chelation-zinc-loss","predicate":"reduced","statement":"Zinc concentration fell during chelation and zinc sulfate was added.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"ded774fe-8e4a-578d-941d-184f4b199438","mechanism_event_label":"Treatment aimed at manganese also lowered another essential mineral.","subject":{"id":"711686eb-bcb3-5671-9ae3-ecce509d4b4c","slug":"calcium-disodium-edetate","display_name":"Calcium disodium edetate","entity_type_key":"chemical_species"},"object":{"id":"63f70463-7397-58fe-b9c2-e60ee6cb0d7b","slug":"measured-zinc-concentration","display_name":"Measured zinc concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ded774fe-8e4a-578d-941d-184f4b199438","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-chelation-zinc-loss-event","event_type":"observed_intervention","label":"Treatment aimed at manganese also lowered another essential mineral.","description":"Zinc concentration fell during chelation and zinc sulfate was added.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"affected_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f0459455-8231-513b-8214-7ea5b3259b4b","slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"},"role":"target_of_treatment","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"711686eb-bcb3-5671-9ae3-ecce509d4b4c","slug":"calcium-disodium-edetate","display_name":"Calcium disodium edetate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"63f70463-7397-58fe-b9c2-e60ee6cb0d7b","slug":"measured-zinc-concentration","display_name":"Measured zinc concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Zinc (affected_nutrient); Manganese (target_of_treatment)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/manganese-clinical-sources/stamelou2012.txt\", \"locator\": \"Clinical description; zinc fell during chelation\", \"file_sha256\": \"5d86a26fe564508fb382d1c8df61f531bfbaf06b69e2078b0999e3a3129555f6\", \"start_char\": 9745, \"end_char\": 9841, \"text_sha256\": \"7ef45c204f1cf372e58dcedb502d4047ace972fd9321bd2af7ccbda75d349439\", \"text_characters\": 96}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ten-year longitudinal report of one SLC30A10 patient","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Calcium disodium edetate chelation; subsequent increase in chelation frequency and addition of oral ferrous fumarate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Repeated observations in one previously described patient. Combined treatment changes prevent attribution of later benefit to iron alone; disease-specific treatment is not routine nutrient replacement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Manganese research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Treatment aimed at manganese also lowered another essential mineral.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mn-clin-stamelou2012] Dystonia with brain manganese accumulation resulting from SLC30A10 mutations: a new treatable disorder. 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Combined treatment changes prevent attribution of later benefit to iron alone; disease-specific treatment is not routine nutrient replacement.\nexposure: Calcium disodium edetate chelation; subsequent increase in chelation frequency and addition of oral ferrous fumarate.\ncross_nutrient: Zinc (affected_nutrient); Manganese (target_of_treatment)\nevidence_span: {\"source_cache\": \"artifacts/manganese-clinical-sources/stamelou2012.txt\", \"locator\": \"Clinical description; zinc fell during chelation\", \"file_sha256\": \"5d86a26fe564508fb382d1c8df61f531bfbaf06b69e2078b0999e3a3129555f6\", \"start_char\": 9745, \"end_char\": 9841, \"text_sha256\": \"7ef45c204f1cf372e58dcedb502d4047ace972fd9321bd2af7ccbda75d349439\", \"text_characters\": 96}\n[mn-clin-stamelou2012] Dystonia with brain manganese accumulation resulting from SLC30A10 mutations: a new treatable disorder. 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