{"id":"5c06c2d7-d517-58f5-9258-a4b28d21fb9c","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-block-8h","predicate":"reduces","statement":"KI at +8 hours produced mean thyroid radiation-dose reduction of 25.4% in the timing comparison.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"af2b5f89-8e61-5661-a510-1e0a19a9f658","mechanism_event_label":"The timing of iodide delivery changed thyroid protection.","subject":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"object":{"id":"8db59d15-15f0-524c-8316-d19722f7a0ee","slug":"thyroid-radioiodine-absorbed-dose","display_name":"Thyroid absorbed radiation dose from radioiodine","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"af2b5f89-8e61-5661-a510-1e0a19a9f658","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-block-8h-event","event_type":"observed_relationship","label":"The timing of iodide delivery changed thyroid protection.","description":"KI at +8 hours produced mean thyroid radiation-dose reduction of 25.4% in the timing comparison.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8db59d15-15f0-524c-8316-d19722f7a0ee","slug":"thyroid-radioiodine-absorbed-dose","display_name":"Thyroid absorbed radiation dose from radioiodine","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"27 healthy adults, 48 paired kinetic assessments; 100 mg KI at specified times relative to radioiodine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Tracer/dosimetry study, not cancer outcomes; timings are experimental, not personal instructions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"The timing of iodide delivery changed thyroid protection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Facing the nuclear threat: thyroid blocking revisited. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21865356/ · DOI 10.1210/jc.2011-1539","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"544cb9f5-9005-5fb6-9a5e-d6dc8cdda860","evidence_kind":"source_excerpt","locator":"Lines 368-374","start_line":368,"end_line":374,"excerpt":"## ki-block-8h\nThe timing of iodide delivery changed thyroid protection.\nKI at +8 hours produced mean thyroid radiation-dose reduction of 25.4% in the timing comparison.\nModel: 27 healthy adults, 48 paired kinetic assessments; 100 mg KI at specified times relative to radioiodine.\nLimitations: Tracer/dosimetry study, not cancer outcomes; timings are experimental, not personal instructions.\nEvidence location: Primary abstract\nFacing the nuclear threat: thyroid blocking revisited. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21865356/ · DOI 10.1210/jc.2011-1539","model_system":"27 healthy adults, 48 paired kinetic assessments; 100 mg KI at specified times relative to radioiodine.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text.","file_path":"","sha256":"3ff9da818dd7a763a59c6abcff2eaee136d7f887a777034feaa5ba304a8fa6ce","revision_id":"53f2ae88-8a91-5326-ac49-3bb510ca78c3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}