{"id":"5bd359eb-315a-5882-ad13-a7aa265ff565","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-diet-brain-vitc","predicate":"deficiency-reduces","statement":"Chronic prenatal and postnatal vitamin C restriction lowered brain total vitamin C in day-70 female guinea pigs.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"4760f668-cec5-51af-9e4c-897682c43106","mechanism_event_label":"Long-term low intake reduced the brain vitamin C pool.","subject":{"id":"da1a7137-08f2-5a36-8bb6-377fbd32e327","slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"},"object":{"id":"1c6d927d-45f8-5744-8b42-b48855dc8106","slug":"brain-total-vitamin-c-content","display_name":"Brain total vitamin C content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4760f668-cec5-51af-9e4c-897682c43106","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-diet-brain-vitc-event","event_type":"observed_intervention","label":"Long-term low intake reduced the brain vitamin C pool.","description":"Chronic prenatal and postnatal vitamin C restriction lowered brain total vitamin C in day-70 female guinea pigs.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"38d0c4d9-53d1-5239-bfe3-c1b5e9b79085","slug":"ascorbate","display_name":"L-Ascorbate","entity_type_key":"small_molecule"},"role":"reduced pool","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e6658c2b-ccff-5122-80a5-2e153f12ba90","slug":"dehydroascorbic-acid","display_name":"Dehydroascorbic acid","entity_type_key":"small_molecule"},"role":"oxidized pool","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"da1a7137-08f2-5a36-8bb6-377fbd32e327","slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1c6d927d-45f8-5744-8b42-b48855dc8106","slug":"brain-total-vitamin-c-content","display_name":"Brain total vitamin C content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Thirty female guinea pig offspring, control/deficient/repleted diets, postnatal day 70","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Prenatal/postnatal 100/100 mg vitamin C/kg diet versus 900/750 mg/kg controls; female offspring at day 70","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Non-scorbutic dietary model; total vitamin C includes reduced and oxidized forms.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Cavia porcellus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Long-term low intake reduced the brain vitamin C pool.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[brain2014] Chronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression. (2014). https://pubmed.ncbi.nlm.nih.gov/24787032/ DOI: 10.3390/nu6051809","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brain","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e994be3e-596f-51c1-9953-f0be728b4b28","evidence_kind":"source_excerpt","locator":"Lines 455-466","start_line":455,"end_line":466,"excerpt":"### vc-transport-diet-brain-vitc\nChronic prenatal and postnatal vitamin C restriction lowered brain total vitamin C in day-70 female guinea pigs.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Long-term low intake reduced the brain vitamin C pool.\norganism: Cavia porcellus\ntissue_or_cell_type: Brain\nexperimental_model: Thirty female guinea pig offspring, control/deficient/repleted diets, postnatal day 70\nlimitations: Non-scorbutic dietary model; total vitamin C includes reduced and oxidized forms.\nexposure: Prenatal/postnatal 100/100 mg vitamin C/kg diet versus 900/750 mg/kg controls; female offspring at day 70\ncross_nutrient: false\n[brain2014] Chronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression. (2014). https://pubmed.ncbi.nlm.nih.gov/24787032/ DOI: 10.3390/nu6051809","model_system":"Thirty female guinea pig offspring, control/deficient/repleted diets, postnatal day 70","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [brain2014] Chronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression. (2014). https://pubmed.ncbi.nlm.nih.gov/24787032/ DOI: 10.3390/nu6051809","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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