{"id":"5ba4276d-4d9c-5ef5-81bd-c125e11fa950","stable_key":"5d8e27d8-6a74-5560-827f-3f90908bbc34:ala-bmi-secondary-effect","predicate":"reduces_secondary_measure","statement":"BMI decreased more with R-lipoic acid than placebo, by approximately 0.8 kg/m² between groups, as a secondary outcome.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"85172ef4-2399-5c12-8588-3d8f961e9d38","mechanism_event_label":"A modest weight-related signal accompanied a negative primary result.","subject":{"id":"8eeb8f85-a924-5122-9399-a757b83c668c","slug":"r-lipoic-acid","display_name":"Free R-alpha-lipoic acid","entity_type_key":"small_molecule"},"object":{"id":"05295e1b-d856-5081-9c6a-5f8966f71b46","slug":"body-mass-index","display_name":"Body mass index","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"85172ef4-2399-5c12-8588-3d8f961e9d38","stable_key":"5d8e27d8-6a74-5560-827f-3f90908bbc34:ala-bmi-secondary-effect-event","event_type":"observed_intervention","label":"A modest weight-related signal accompanied a negative primary result.","description":"BMI decreased more with R-lipoic acid than placebo, by approximately 0.8 kg/m² between groups, as a secondary outcome.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8eeb8f85-a924-5122-9399-a757b83c668c","slug":"r-lipoic-acid","display_name":"Free R-alpha-lipoic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"05295e1b-d856-5081-9c6a-5f8966f71b46","slug":"body-mass-index","display_name":"Body mass index","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ala-research/32692358.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4054eff822014466ea739125fd4000ba2a5852e5f9818487f0b32b7be2b8d076\", \"start_char\": 0, \"end_char\": 2088, \"text_sha256\": \"4054eff822014466ea739125fd4000ba2a5852e5f9818487f0b32b7be2b8d076\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized placebo-controlled R-lipoic-acid trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"R-lipoic acid 600 mg/day for 24 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Primary triglyceride outcome was null; BMI was secondary and subgroup findings are exploratory.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lipoic-acid","display_name":"Lipoic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A modest weight-related signal accompanied a negative primary result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ala-p32692358] A Randomized Controlled Trial of Long-Term (R)-α-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations. (2020). https://pubmed.ncbi.nlm.nih.gov/32692358/ DOI: 10.1093/jn/nxaa203","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"81 overweight adults with elevated triglycerides","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1eea19e8-cfa0-5ce6-80d1-b76936ee1f81","evidence_kind":"source_excerpt","locator":"Lines 1222-1233","start_line":1222,"end_line":1233,"excerpt":"### ala-bmi-secondary-effect\nBMI decreased more with R-lipoic acid than placebo, by approximately 0.8 kg/m² between groups, as a secondary outcome.\nCondition category: normal\nnutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A modest weight-related signal accompanied a negative primary result.\norganism: Human\ntissue_or_cell_type: 81 overweight adults with elevated triglycerides\nexperimental_model: Randomized placebo-controlled R-lipoic-acid trial\nlimitations: Primary triglyceride outcome was null; BMI was secondary and subgroup findings are exploratory.\nexposure: R-lipoic acid 600 mg/day for 24 weeks\nevidence_span: {\"source_cache\": \"artifacts/ala-research/32692358.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4054eff822014466ea739125fd4000ba2a5852e5f9818487f0b32b7be2b8d076\", \"start_char\": 0, \"end_char\": 2088, \"text_sha256\": \"4054eff822014466ea739125fd4000ba2a5852e5f9818487f0b32b7be2b8d076\"}\n[ala-p32692358] A Randomized Controlled Trial of Long-Term (R)-α-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations. 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