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Cannot attribute the effect to either ingredient or prove biochemical synergy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Theanine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"34 children with Tourette syndrome or chronic tic disorder and anxiety","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This preliminary combination result does not show that B6 makes theanine work in everyone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[theanine-p35215501] Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study. (2022). https://pubmed.ncbi.nlm.nih.gov/35215501/ DOI: 10.3390/nu14040852","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Clinician-rated tics and anxiety","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4c9be7e0-9136-5bc8-b819-450cfe0c0169","evidence_kind":"source_excerpt","locator":"Lines 874-885","start_line":874,"end_line":885,"excerpt":"### theanine-b6-mixture-tics\nThe mixture group improved clinician-rated tics more than psychoeducation in the open-label trial.\nCondition category: normal\nnutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This preliminary combination result does not show that B6 makes theanine work in everyone.\norganism: 34 children with Tourette syndrome or chronic tic disorder and anxiety\ntissue_or_cell_type: Clinician-rated tics and anxiety\nexperimental_model: Randomized open-label comparative trial\nlimitations: No blinded placebo and no single-ingredient arms. Cannot attribute the effect to either ingredient or prove biochemical synergy.\nexposure: Theanine plus vitamin B6 versus psychoeducation\nevidence_span: {\"source_cache\": \"artifacts/theanine-research/35215501.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"68809f3eaf29616aa35c472872e3c510e0c8aaf23e8880c43a91f363eaad5ea2\", \"start_char\": 0, \"end_char\": 1576, \"text_sha256\": \"68809f3eaf29616aa35c472872e3c510e0c8aaf23e8880c43a91f363eaad5ea2\"}\n[theanine-p35215501] Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study. (2022). https://pubmed.ncbi.nlm.nih.gov/35215501/ DOI: 10.3390/nu14040852","model_system":"Randomized open-label comparative trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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