{"id":"5b612f89-7b0c-56b9-aee6-6703e32cb097","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:fol-hope2-homocysteine","predicate":"combined_b_vitamins_lowered_homocysteine","statement":"Mean homocysteine fell 2.4 micromol/L with the combined B vitamins and rose 0.8 micromol/L with placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"a258548c-8d79-5c55-ae49-6b9827fbc41d","mechanism_event_label":"The biochemical target changed in the trial.","subject":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"object":{"id":"5b635b42-bc0d-5c54-aa94-9cf76cd0ed47","slug":"homocysteine","display_name":"Homocysteine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"a258548c-8d79-5c55-ae49-6b9827fbc41d","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:fol-hope2-homocysteine-event","event_type":"observed_intervention","label":"The biochemical target changed in the trial.","description":"Mean homocysteine fell 2.4 micromol/L with the combined B vitamins and rose 0.8 micromol/L with placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"role":"cointervention","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b6d9b937-895d-5e0a-8cc5-0454a0b7d373","slug":"vitamin-b12","display_name":"Vitamin B12 (cobalamins)","entity_type_key":"chemical_species"},"role":"cointervention","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5b635b42-bc0d-5c54-aa94-9cf76cd0ed47","slug":"homocysteine","display_name":"Homocysteine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Directly records the combined B6/B12/folic-acid exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized HOPE-2: 5522 adults at least 55 years old with vascular disease or diabetes, mean five years.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Folic acid 2.5 mg, B6 50 mg and B12 1 mg/day together versus placebo; 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topical membership is not evidence of a direct dietary effect.\nplain_language: The biochemical target changed in the trial.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person clinical endpoints\nexperimental_model: Randomized HOPE-2: 5522 adults at least 55 years old with vascular disease or diabetes, mean five years.\nlimitations: Folate, B6 and B12 were administered together; their individual contributions cannot be separated.\nexposure: Folic acid 2.5 mg, B6 50 mg and B12 1 mg/day together versus placebo; combined intervention, not isolated folate.\ncross_nutrient: Directly records the combined B6/B12/folic-acid exposure.\n[fol-hope2006] Homocysteine lowering with folic acid and B vitamins in vascular disease (2006). https://pubmed.ncbi.nlm.nih.gov/16531613/ DOI: 10.1056/nejmoa060900","model_system":"Randomized HOPE-2: 5522 adults at least 55 years old with vascular disease or diabetes, mean five years.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [fol-hope2006] Homocysteine lowering with folic acid and B vitamins in vascular disease (2006). https://pubmed.ncbi.nlm.nih.gov/16531613/ DOI: 10.1056/nejmoa060900","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f4ce1a62-9582-5f7a-84f5-a23d0e1bfc68","stable_key":"import-ec174d5a-4903-5745-8646-df0e9d4265e8","title":"Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e564d43989ece1006c95cd0748e9af6fe369074599a2eebba0a99ebff864b0dd","revision_id":"76674a33-b2a1-5e41-b71b-44399038ff7c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}