{"id":"5b15875e-5b34-5412-9670-9c513f509c05","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:tacrolimus-forms-the-fkbp-complex","predicate":"forms","statement":"FK506 likewise acts by forming a drug-dependent complex with FKBP, and it is that complex, not the free drug, that binds and inhibits calcineurin.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"7678b8dc-b92f-5910-ae10-22bffc8314a9","mechanism_event_label":"FK506 likewise acts by forming a drug-dependent complex with FKBP, and it is that complex, not the free drug, that binds and inhibits calcineurin.","subject":{"id":"de397950-f184-58bd-a815-27d052ecc59d","slug":"tacrolimus","display_name":"Tacrolimus / FK506","entity_type_key":"drug"},"object":{"id":"2ba4a540-b7b8-5f7d-b359-274b207ae9d2","slug":"fkbp-fk506","display_name":"FKBP-FK506 complex","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"7678b8dc-b92f-5910-ae10-22bffc8314a9","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:tacrolimus-forms-the-fkbp-complex-event","event_type":"biochemical_relationship","label":"FK506 likewise acts by forming a drug-dependent complex with FKBP, and it is that complex, not the free drug, that binds and inhibits calcineurin.","description":"Formation of the drug-immunophilin complex","status":"provisional","compartment":null,"participants":[{"entity":{"id":"de397950-f184-58bd-a815-27d052ecc59d","slug":"tacrolimus","display_name":"Tacrolimus / FK506","entity_type_key":"drug"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2ba4a540-b7b8-5f7d-b359-274b207ae9d2","slug":"fkbp-fk506","display_name":"FKBP-FK506 complex","entity_type_key":"protein_complex"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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No reference carries a recorded retraction, erratum or expression of concern. Each of the seven is a separate laboratory and each carries its own lineage key, so none of them can be counted twice as independent support. Study-specific concentrations, kinetic constants and limitations retained. Not publisher full text.","file_path":"","sha256":"499d00555a629cba2271c3888d7e93627949891d565c4c78c843610de2913080","revision_id":"263ee68a-4184-51d0-a977-197d7ddb7a4d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}