{"id":"5b118654-b717-5080-8d99-e72576be501f","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-insulin-heterogeneity","predicate":"has_variable_association_with","statement":"C-peptide-based insulin secretion did not differ on average: four participants increased and five decreased in the MSG-plus-carbohydrate condition.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"4b7b3e3d-428a-55b2-a303-76456a2c32f9","mechanism_event_label":"The average and individual responses tell different parts of the story.","subject":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"object":{"id":"908e8ea2-0107-59e0-9767-14ff24615a32","slug":"human-staggered-msg-insulin-secretion","display_name":"Human insulin-secretion estimates after staggered MSG","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4b7b3e3d-428a-55b2-a303-76456a2c32f9","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-insulin-heterogeneity-event","event_type":"observed_relationship","label":"The average and individual responses tell different parts of the story.","description":"C-peptide-based insulin secretion did not differ on average: four participants increased and five decreased in the MSG-plus-carbohydrate condition.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"908e8ea2-0107-59e0-9767-14ff24615a32","slug":"human-staggered-msg-insulin-secretion","display_name":"Human insulin-secretion estimates after staggered MSG","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same nine men; C-peptide interpretation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not identify responder genotypes or a direct insulin-receptor target.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The average and individual responses tell different parts of the story.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Glutamate supplementation is associated with improved glucose metabolism following carbohydrate ingestion in healthy males. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23750536/ · DOI 10.1017/S0007114513001633","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d6a8590f-d1fd-58b0-9a64-a5d1c99dea1d","evidence_kind":"source_excerpt","locator":"Lines 66-72","start_line":66,"end_line":72,"excerpt":"## monosodium-glutamate-insulin-heterogeneity\nThe average and individual responses tell different parts of the story.\nC-peptide-based insulin secretion did not differ on average: four participants increased and five decreased in the MSG-plus-carbohydrate condition.\nModel: Same nine men; C-peptide interpretation.\nLimitations: This does not identify responder genotypes or a direct insulin-receptor target.\nEvidence access: Primary abstract\nGlutamate supplementation is associated with improved glucose metabolism following carbohydrate ingestion in healthy males. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23750536/ · DOI 10.1017/S0007114513001633","model_system":"Same nine men; C-peptide interpretation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"90a81fe5-8622-52f6-b4db-04899206c2b0","stable_key":"import-561b2b40-5b59-548f-a749-f357f7e2304c","title":"Monosodium Glutamate (MSG): taste, gut sensing, exposure and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"53052c19ee82d400eff7d82ffa3cff74747c7f91a8d173efa3f46eba6bd87cce","revision_id":"fdb64139-32f4-537e-bb0f-f242f2779da8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}