{"id":"5b0c2254-00dc-5d32-a1ab-70fee6bd9ff4","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-b0at1-transport","predicate":"cotransports","statement":"SLC6A19 functioned as a sodium-dependent, chloride-independent neutral amino acid transporter.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"48eea9cb-5acc-5a88-9e4b-355d56f31abb","mechanism_event_label":"Sodium coupling is also used to absorb or recover some amino acids.","subject":{"id":"10307ad9-80a3-56be-a7f5-740c9362297f","slug":"slc6a19","display_name":"Human neutral amino acid transporter B0AT1 / SLC6A19","entity_type_key":"protein"},"object":{"id":"6b9522d7-e31d-566e-afae-c5988c3fa740","slug":"neutral-amino-acids","display_name":"Neutral amino acids (assay substrates specified per claim)","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"48eea9cb-5acc-5a88-9e4b-355d56f31abb","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-b0at1-transport-event","event_type":"biochemical_relationship","label":"Sodium coupling is also used to absorb or recover some amino acids.","description":"SLC6A19 functioned as a sodium-dependent, chloride-independent neutral amino acid transporter.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"coupling_ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"10307ad9-80a3-56be-a7f5-740c9362297f","slug":"slc6a19","display_name":"Human neutral amino acid transporter B0AT1 / SLC6A19","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6b9522d7-e31d-566e-afae-c5988c3fa740","slug":"neutral-amino-acids","display_name":"Neutral amino acids (assay substrates specified per claim)","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/sodium-research/15286788.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"72277489510231d6da07dacf086404f5f069094a47d7a1a2de9a8392556c3a14\", \"start_char\": 0, \"end_char\": 1040, \"text_sha256\": \"72277489510231d6da07dacf086404f5f069094a47d7a1a2de9a8392556c3a14\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human genetic mapping and heterologous transport-function tests","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Hartnup-associated variants versus normal transporter","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not every clinical feature of Hartnup disorder was explained; no direct test here of niacin supplementation or sodium shortage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sodium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human SLC6A19","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Sodium coupling is also used to absorb or recover some amino acids.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sodium-p15286788] Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19. (2004). https://pubmed.ncbi.nlm.nih.gov/15286788/ DOI: 10.1038/ng1406","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Kidney/intestine transporter; expression assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"Sodium-dependent neutral amino acid transport, which is inward.","entity":null},{"dimension":"transport_pool","value_text":"the expressing cell","comparator":null,"unit":null,"notes":"Sodium-dependent neutral amino acid transport, which is inward.","entity":null}],"evidence":[{"id":"495d4ea3-afa8-58a6-ad85-e2c4e3e26d33","evidence_kind":"source_excerpt","locator":"Lines 590-601","start_line":590,"end_line":601,"excerpt":"### sodium-b0at1-transport\nSLC6A19 functioned as a sodium-dependent, chloride-independent neutral amino acid transporter.\nCondition category: normal\nnutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Sodium coupling is also used to absorb or recover some amino acids.\norganism: Human SLC6A19\ntissue_or_cell_type: Kidney/intestine transporter; expression assays\nexperimental_model: Human genetic mapping and heterologous transport-function tests\nlimitations: Not every clinical feature of Hartnup disorder was explained; no direct test here of niacin supplementation or sodium shortage.\nexposure: Hartnup-associated variants versus normal transporter\nevidence_span: {\"source_cache\": \"artifacts/sodium-research/15286788.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"72277489510231d6da07dacf086404f5f069094a47d7a1a2de9a8392556c3a14\", \"start_char\": 0, \"end_char\": 1040, \"text_sha256\": \"72277489510231d6da07dacf086404f5f069094a47d7a1a2de9a8392556c3a14\"}\n[sodium-p15286788] Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19. (2004). https://pubmed.ncbi.nlm.nih.gov/15286788/ DOI: 10.1038/ng1406","model_system":"Human genetic mapping and heterologous transport-function tests","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [sodium-p15286788] Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19. (2004). https://pubmed.ncbi.nlm.nih.gov/15286788/ DOI: 10.1038/ng1406","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c260cd7b-beb0-5113-a198-69ec8fd4492c","stable_key":"import-195e8b84-ca5a-591a-a045-c55c53c8a01c","title":"Sodium: gradients, nutrient transport, fluid regulation and loss states (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"684f65cf0661c18395831ade4b02bb24d5e66c568f0d00a3471600eaf5d4d1c6","revision_id":"39866f04-3052-5f59-bd95-6806c5490875","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}