{"id":"5b093be6-6113-553d-bbe9-21cd1c692e16","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-sod3-vascular-relaxation","predicate":"gene_transfer_rescues","statement":"SOD3 gene transfer rescued impaired endothelium-dependent relaxation in the tested diabetic mouse arteries.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"787d6186-4c65-5f0c-a864-f1e22bab0e24","mechanism_event_label":"The extracellular antioxidant system helped the blood vessel respond normally.","subject":{"id":"d0d2556c-5006-5e20-8ad1-ac84e66677fd","slug":"mouse-sod3","display_name":"Mouse extracellular superoxide dismutase Sod3","entity_type_key":"protein"},"object":{"id":"30461d62-6c31-59af-b8e3-d1d345088639","slug":"mouse-endothelial-relaxation","display_name":"Mouse endothelium-dependent vascular relaxation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"787d6186-4c65-5f0c-a864-f1e22bab0e24","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-sod3-vascular-relaxation-event","event_type":"biochemical_relationship","label":"The extracellular antioxidant system helped the blood vessel respond normally.","description":"SOD3 gene transfer rescued impaired endothelium-dependent relaxation in the tested diabetic mouse arteries.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d0d2556c-5006-5e20-8ad1-ac84e66677fd","slug":"mouse-sod3","display_name":"Mouse extracellular superoxide dismutase Sod3","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"30461d62-6c31-59af-b8e3-d1d345088639","slug":"mouse-endothelial-relaxation","display_name":"Mouse endothelium-dependent vascular relaxation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/copper-research/23884884.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"85b24243a5eec9d9447299976023325f133d18d979f5be612845f4d2bbc28249\", \"start_char\": 0, \"end_char\": 1831, \"text_sha256\": \"85b24243a5eec9d9447299976023325f133d18d979f5be612845f4d2bbc28249\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Genetic and streptozotocin diabetes mouse models with vascular rescue assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Diabetes, Atp7a overexpression, copper or insulin ex vivo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Local transporter loss and hypoinsulinemia are not proof of dietary copper deficiency or a human supplementation effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The extracellular antioxidant system helped the blood vessel respond normally.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p23884884] Copper transporter ATP7A protects against endothelial dysfunction in type 1 diabetic mice by regulating extracellular superoxide dismutase. (2013). https://pubmed.ncbi.nlm.nih.gov/23884884/ DOI: 10.2337/db12-1228","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Aortas, mesenteric vessels and vascular smooth muscle","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"b5255a98-46aa-585a-83cb-339f7b90fbe6","evidence_kind":"source_excerpt","locator":"Lines 962-973","start_line":962,"end_line":973,"excerpt":"### copper-sod3-vascular-relaxation\nSOD3 gene transfer rescued impaired endothelium-dependent relaxation in the tested diabetic mouse arteries.\nCondition category: machinery_impairment\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The extracellular antioxidant system helped the blood vessel respond normally.\norganism: Mouse\ntissue_or_cell_type: Aortas, mesenteric vessels and vascular smooth muscle\nexperimental_model: Genetic and streptozotocin diabetes mouse models with vascular rescue assays\nlimitations: Local transporter loss and hypoinsulinemia are not proof of dietary copper deficiency or a human supplementation effect.\nexposure: Diabetes, Atp7a overexpression, copper or insulin ex vivo\nevidence_span: {\"source_cache\": \"artifacts/copper-research/23884884.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"85b24243a5eec9d9447299976023325f133d18d979f5be612845f4d2bbc28249\", \"start_char\": 0, \"end_char\": 1831, \"text_sha256\": \"85b24243a5eec9d9447299976023325f133d18d979f5be612845f4d2bbc28249\"}\n[copper-p23884884] Copper transporter ATP7A protects against endothelial dysfunction in type 1 diabetic mice by regulating extracellular superoxide dismutase. (2013). https://pubmed.ncbi.nlm.nih.gov/23884884/ DOI: 10.2337/db12-1228","model_system":"Genetic and streptozotocin diabetes mouse models with vascular rescue assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [copper-p23884884] Copper transporter ATP7A protects against endothelial dysfunction in type 1 diabetic mice by regulating extracellular superoxide dismutase. (2013). https://pubmed.ncbi.nlm.nih.gov/23884884/ DOI: 10.2337/db12-1228","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9afba495-cbdc-51aa-998e-70a930dba3be","stable_key":"import-0ad8610d-d575-5870-b7cd-763a9f750783","title":"Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"84b0f62b2dae6835fa26902be87625c003c6c707492d3007e8f9d15420669008","revision_id":"d7e35b8b-3f77-56d9-90b5-5f542c63f321","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}