{"id":"5af13fda-07a5-559f-b62b-e20c63a747f4","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-iodine-nadh","predicate":"oxidizes","statement":"Molecular iodine oxidized NADH without enzyme and was proposed as an intermediate of iodide-dependent oxidation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5a144f58-aa38-5723-bc4b-a2f8add93e1c","mechanism_event_label":"Oxidized iodine can carry the reaction onward.","subject":{"id":"b3b7bd55-2e97-5df1-886f-c938fba10e2d","slug":"molecular-iodine","display_name":"Molecular iodine (I2)","entity_type_key":"chemical_species"},"object":{"id":"9fbf2e03-16a9-5ca7-965c-0bfc07ca24da","slug":"nadh","display_name":"NADH","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"5a144f58-aa38-5723-bc4b-a2f8add93e1c","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-iodine-nadh-event","event_type":"observed_relationship","label":"Oxidized iodine can carry the reaction onward.","description":"Molecular iodine oxidized NADH without enzyme and was proposed as an intermediate of iodide-dependent oxidation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b3b7bd55-2e97-5df1-886f-c938fba10e2d","slug":"molecular-iodine","display_name":"Molecular iodine (I2)","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9fbf2e03-16a9-5ca7-965c-0bfc07ca24da","slug":"nadh","display_name":"NADH","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Cell-free LPO/H2O2 reactions with nicotinamide nucleotides.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Chemical oxidation is not evidence that supplementation drains niacin in vivo; the authors expected thiocyanate oxidation to predominate in milk/saliva.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Oxidized iodine can carry the reaction onward.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The oxidation of reduced nicotinamide nucleotides by hydrogen peroside in the presence of lactoperoxidase and thiocyanate, iodide or bromide. · 1970 · https://pubmed.ncbi.nlm.nih.gov/4317722/ · DOI 10.1042/bj1170791","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6ae23fb3-badb-50cc-82d6-50df198de0db","evidence_kind":"source_excerpt","locator":"Lines 272-278","start_line":272,"end_line":278,"excerpt":"## ki-iodine-nadh\nOxidized iodine can carry the reaction onward.\nMolecular iodine oxidized NADH without enzyme and was proposed as an intermediate of iodide-dependent oxidation.\nModel: Cell-free LPO/H2O2 reactions with nicotinamide nucleotides.\nLimitations: Chemical oxidation is not evidence that supplementation drains niacin in vivo; the authors expected thiocyanate oxidation to predominate in milk/saliva.\nEvidence location: Primary abstract\nThe oxidation of reduced nicotinamide nucleotides by hydrogen peroside in the presence of lactoperoxidase and thiocyanate, iodide or bromide. · 1970 · https://pubmed.ncbi.nlm.nih.gov/4317722/ · DOI 10.1042/bj1170791","model_system":"Cell-free LPO/H2O2 reactions with nicotinamide nucleotides.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text.","file_path":"","sha256":"3ff9da818dd7a763a59c6abcff2eaee136d7f887a777034feaa5ba304a8fa6ce","revision_id":"53f2ae88-8a91-5326-ac49-3bb510ca78c3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}